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Zhi-hong WU, Hai-yan CHENG, Ju-tai WU, Yi-peng WANG, Gui-xing QIU. Expressions of Calcium-binding Protein and Related Protein in the Endplate Cartilage of Patients with Idiopathic Scoliosis[J]. Medical Journal of Peking Union Medical College Hospital, 2011, 2(1): 1-6. DOI: 10.3969/j.issn.1674-9081.2011.01.001
Citation: Zhi-hong WU, Hai-yan CHENG, Ju-tai WU, Yi-peng WANG, Gui-xing QIU. Expressions of Calcium-binding Protein and Related Protein in the Endplate Cartilage of Patients with Idiopathic Scoliosis[J]. Medical Journal of Peking Union Medical College Hospital, 2011, 2(1): 1-6. DOI: 10.3969/j.issn.1674-9081.2011.01.001
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Expressions of Calcium-binding Protein and Related Protein in the Endplate Cartilage of Patients with Idiopathic Scoliosis

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    • Abstract
  •   Objective  To observe the expression of S100A8, heat shock protein(HSP)90, and calmodulin(CaM)in the discs endplate cartilage of patients with idiopathic scoliosis(IS)and congenital scoliosis(CS).
      Methods  The discs of 4 IS patients(diagnosed by clinical and radiological data)and 4 CS patients who had undergone anterior-route surgeries were collected.Total protein was extracted from endplate cartilage with TRIzol method.The expressions of S100A8, HSP90, and CaM genes in the cartilages were analyzed using Western blot.
      Results  The expressions of HSP90 and CaM in the cartilages were not significantly different between CS patients and IS patients, while the expression of S100A8 was significantly higher in IS patients than that in CS patients.
      Conclusion  S100A8 may play a role in the occurrence and development of IS.
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