CAO Yan, CHEN Yu, YI Jie, KONG Lingjun, WANG Ziyi, ZHANG Rui, YU Qi, LIU Yiwei, MULATIJIANG Maimaiti, YANG Chenglin, SUN Yujie, XU Yingchun, YANG Qiwen, DU Juan. Pathogenic Agents Causing Acute Respiratory Tract Infections in Beijing During Autumn and Winter of 2023 to 2024:A Study of 5,556 Patients from Peking Union Medical College Hospital[J]. Medical Journal of Peking Union Medical College Hospital. DOI: 10.12290/xhyxzz.2024-0529
Citation: CAO Yan, CHEN Yu, YI Jie, KONG Lingjun, WANG Ziyi, ZHANG Rui, YU Qi, LIU Yiwei, MULATIJIANG Maimaiti, YANG Chenglin, SUN Yujie, XU Yingchun, YANG Qiwen, DU Juan. Pathogenic Agents Causing Acute Respiratory Tract Infections in Beijing During Autumn and Winter of 2023 to 2024:A Study of 5,556 Patients from Peking Union Medical College Hospital[J]. Medical Journal of Peking Union Medical College Hospital. DOI: 10.12290/xhyxzz.2024-0529

Pathogenic Agents Causing Acute Respiratory Tract Infections in Beijing During Autumn and Winter of 2023 to 2024:A Study of 5,556 Patients from Peking Union Medical College Hospital

Funds: 

National Key Research and Development Program: Establishment of a Hierarchical Analysis Pipeline for Acute Infectious Disease Pathogens Based on Genomics(2022YFC2305301)

More Information
  • Received Date: July 11, 2024
  • Accepted Date: August 07, 2024
  • Available Online: December 09, 2024
  • Objective To investigate the pathogen spectrum of acute respiratory infections in Beijing during autumn and winter of 2023 to 2024. The findings will provide valuable insights for clinical diagnosis, treatment, prevention and control of respiratory infectious diseases through epidemiological analysis. Methods This study focused on patients who visited Peking Union Medical College Hospital for acute respiratory infections from September 2023 to February 2024 by convenience sampling.We used fluorescence quantitative PCR to detect six respiratory pathogens, namely influenza A virus (FluA), influenza B virus (FluB), Human rhinovirus (HRV), Mycoplasma pneumoniae (MP), respiratory syncytial virus (RSV), and adenovirus (ADV), in 5556 respiratory tract samples collected from patients with respiratory tract infections. Additionally, we analyzed the distribution of pathogen infections by combining the results with COVID-19 infections during the same period. Results Among the 5556 samples, the overall positive rate was 63.7%. The positive rates for single pathogen infections, dual pathogen infections, and infections with three or more pathogens were 54.0%, 8.9%, and 0.7% respectively. In terms of overall detection of pathogens, FluA and RSV were the predominant pathogens, with positive rates of 16.1% and 15.7% respectively. The positive rates for ADV, MP, HRV, and FluB were similar, at 11.1%, 11.1%, 10.0%, and 10.0% respectively. Although there was no difference in the overall pathogen positive rate between different genders and seasons, statistical differences were witnessed in the infection rates and pathogen compositions among different age groups (χ2=34.617, P<0.001, χ2=422.38, P<0.001). There were variations in the detection rates of MP, FluA, FluB, and HRV between different seasons (P<0.005). The positive rates of MP(χ2=8.647, P=0.003)、 FluA (χ2=131.932, P<0.001)和 HRV(χ2=174.199, P<0.001) were significantly higher in autumn than in winter, while FluB showed the opposite trend (χ2=287.894, P<0.001), predominantly occurring in winter. The positive rates of MP, RSV, HRV, and ADV in the pediatric group were significantly higher than those in the middleaged and elderly patients (all P <0.001), while the positive rate of FluB in middleaged patients was significantly higher than that in both children and elderly patients (P <0.001 for both). The overall number of cases infected with the six respiratory pathogens decreased significantly during the period of COVID-19 infection, exhibiting an asynchronous seasonal pattern. Conclusion The detection rate of respiratory pathogens in Beijing was related to age and season. Targeted prevention and control measures should be implemented for different populations in different seasons, and early epidemic warnings should be issued.
  • [1]
    Baker RE, Park SW, Yang W, et al. The impact of COVID-19 nonpharmaceutical interventions on the future dynamics of endemic infections[J]. Proceedings of the National Academy of Sciences, 2020, 117:30547-30553.
    [2]
    Lai S, Ruktanonchai NW, Zhou L, et al. Effect of non-pharmaceutical interventions to contain COVID-19 in China[J]. Nature, 2020, 585:410-413.
    [3]
    赵林清,邓莉,曹玲,等.新型冠状病毒肺炎疫情期间北京定点排查医院儿童急性呼吸道感染的病原谱观察[J].中华儿科杂志, 2020, 58:635-639.
    [4]
    姬莉莉,喻金玉,毛玉梅,等. 2015-2020年北京市怀柔区11种呼吸道病原体流行特征分析[J].首都公共卫生, 2022, 16:113-117+127.
    [5]
    武利涛,姚兴伟,李宝萍,等. 2016-2018年北京地区急性呼吸道感染患者病原体流行特征分析[J].中国医药, 2019, 14:1647-1651.
    [6]
    Cai W, Köndgen S, Tolksdorf K, et al. Atypical age distribution and high disease severity in children with RSV infections during two irregular epidemic seasons throughout the COVID-19 pandemic, Germany, 2021 to 2023[J]. Eurosurveillance, 2024, 29:2300465. doi: 10.2807/1560-7917.ES.2024.29.13.2300465.
    [7]
    Wang H, Naghavi M, Allen C, et al. Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015:a systematic analysis for the Global Burden of Disease Study 2015[J]. The Lancet, 2016, 388:1459-1544.
    [8]
    刘思家. 2017-2019年急性呼吸道腺病毒感染临床病例分析与流行特征研究[D].温州:温州医科大学, 2020.
    [9]
    王方明.北京地区儿童人呼吸道腺病毒种系进化特点及腺病毒重组机制研究[D].北京:中国医学科学院, 2023.
    [10]
    付玉林,董艳,李静. 2018-2019年北京市儿童社区获得性肺炎的病原学分析及临床特点[J].中国医药科学, 2022, 12:126-129.
    [11]
    Nickbakhsh S, Mair C, Matthews L, et al. Virus-virus interactions impact the population dynamics of influenza and the common cold[J]. Proceedings of the National Academy of Sciences, 2019, 116:27142-27150.
    [12]
    Piret J, Boivin G. Viral Interference between Respiratory Viruses[J]. Emerging Infectious Diseases, 2022; 28:273-281.
  • Related Articles

    [1]XIAO Chunfeng, WEI Jing. Advances in Clinical Trials and Mechanisms of Music Therapy for Mental Disorders, and Future Directions[J]. Medical Journal of Peking Union Medical College Hospital. DOI: 10.12290/xhyxzz.2024-0695
    [2]ZHANG Shan, LIU Jie. Interpretation of NCCN Clinical Practice Guidelines for Primary Cutaneous Lymphomas (Version 1.2024) Based on the Current Diagnosis and Treatment Status of China[J]. Medical Journal of Peking Union Medical College Hospital, 2024, 15(5): 1029-1037. DOI: 10.12290/xhyxzz.2024-0605
    [3]ZHANG Ning, YANG Chenhao, ZHOU Liangrui, SUN Xiaohong, LIU Xiaohong, KANG Lin, LI Ji, LI Hailong. Cronkhite-Canada Syndrome Combined with Asymptomatic Novel Coronavirus Infection: A Case Report[J]. Medical Journal of Peking Union Medical College Hospital, 2024, 15(2): 406-412. DOI: 10.12290/xhyxzz.2023-0476
    [4]CAO Jinya, DUAN Yanping, WEI Jing. Resident-attending-professor Rounds of Consultation-liaison Psychiatry Service to Provide the Hospitalized Care of Psychiatric Comorbidities of General Hospital Inpatients[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(1): 18-21. DOI: 10.12290/xhyxzz.2022-0578
    [5]ZHAO Zhe, TANG Yan, ZHOU Jingya, CHEN Xiaoguang, ZHANG Lei, CHEN Limeng, YUAN Tao. Analysis of Clinical Manifestations and Drug Therapies of Gitelman Syndrome[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(2): 277-286. DOI: 10.12290/xhyxzz.2021-0180
    [6]Rare Diseases Society of Chinese Research Hospital Association, National Rare Diseases Committee, Beijing Rare Disease Diagnosis, Treatment and Protection Society, Gitelman Syndrome Consensus Working Group. Expert Consensus for the Diagnosis and Treatment of Gitelman Syndrome in China (2021)[J]. Medical Journal of Peking Union Medical College Hospital, 2021, 12(6): 902-912. DOI: 10.12290/xhyxzz.2021-0555
    [8]Ming-sheng MA, Xü-de ZHANG, Min WEI, Shi-min ZHAO, Zheng-qing QIU. Efficacy of Low Dose Corticosteroid Therapy in Duchenne Muscular Dystrophy[J]. Medical Journal of Peking Union Medical College Hospital, 2014, 5(4): 384-388. DOI: 10.3969/j.issn.1674-9081.2014.04.006
    [9]Ying ZHANG, Jin-song GAO, Jun-tao LIU, Hai-yuan LIU, Ying-na SONG, Xiao-ming GONG, Zhi-jing SUN. Effectiveness of B-lynch Suture in Treatment and Prevention of Postpartum Hemorrhage[J]. Medical Journal of Peking Union Medical College Hospital, 2013, 4(2): 174-177. DOI: 10.3969/j.issn.1674-9081.2013.02.019
    [10]Jie LIU, Yue-ping ZENG, Chun-xia HE, Qin LONG, Hong-zhong JIN, Qiu-ning SUN. Corticosteroids plus Intravenous Immunoglobulin in the Treatment of 7 Cases with Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis[J]. Medical Journal of Peking Union Medical College Hospital, 2012, 3(4): 381-385. DOI: 10.3969/j.issn.1674-9081.2012.04.004

Catalog

    Article Metrics

    Article views (298) PDF downloads (28) Cited by()
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return
    x Close Forever Close