| Citation: |
MEI Qimin, DAI Jiayuan, LIU Yecheng, SHEN Min, ZHU Huadong. Atypical Hemolytic Uremic Syndrome with Eosinophilia and Purtscher-like Retinopathy: A Case Report[J]. Medical Journal of Peking Union Medical College Hospital, 2025, 16(1): 256-262. DOI: 10.12290/xhyxzz.2024-0471
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Atypical hemolytic uremic syndrome (aHUS), a rare disease caused by complement abnormalities, is characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury. In this paper, we report a patient with severe renal insufficiency with rapidly progressive decline in binocular visual acuity, who developed eosinophilia during the course of the disease, and was diagnosed with aHUS after excluding other diseases. After glucocorticoid treatment, eosinophils decreased to normal, and after treatment with plasmapheresis combined with eculizumab, renal function tended to be stable, platelets returned to normal, but visual acuity did not improve significantly. This article reviews the diagnosis and treatment process of this patient and incorporates the review of literature, in the hope of providing reference for clinicians.
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China Alliance for Rare Diseases Pediatric Atypical Hemolytic Uremic Syndrome Committee, National Center for Children's Health (Beijing Children's Hospital, Capital Medical University), Editorial Board of Chinese Journal of Applied Clinical Pediatrics. Consensus on the diagnosis and treatment of atypical hemolytic uremic syndrome in Chinese children (2023 edition)[J]. Chin J Appl Clin Pediatr, 2023, 38(6): 401-412. DOI: 10.3760/cma.j.cn101070-20230328-00257
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