| Citation: |
ZHANG Xu, DU Hanze, ZHAI Wenhao, SONG Shuaihua, GUO Xiaoyuan, WEN Linlin, HUANG Lei, CHEN Shi, LI Daowei, PAN Hui. The Correlation between Tooth Brushing Frequency and Blood Indicators in Adolescents: A Cross-sectional Observational Study[J]. Medical Journal of Peking Union Medical College Hospital, 2024, 15(4): 960-967. DOI: 10.12290/xhyxzz.2024-0181
|
To analyze the effects of tooth brushing frequency on blood indicators among adolescents and to preliminarily explore the effects of tooth brushing frequency on general health.
Using convenience sampling method, the study included the students of class 2021 of Jining No. 7 Middle School and student athletes from the Jining Sports Training Center. Univariate and multivariate linear regression analyses were used to investigate the correlation between tooth brushing frequency and blood indicators such as eosinophil percentage (EOS%), eosinophil count (EOS#), basophil percentage (BAS%), basophil count (BAS#), superoxide dismutase (SOD), insulin-like growth factor 1 (IGF-1) and uric acid (UA).
A total of 305 students were included (167 from Jining No. 7 Middle School, 138 from Jining Sports Training Centre), with 192 (62.95%) males and 113 (37.05%) females. They were divided into three groups based on daily teeth brushing frequency: ≤1 time (40.33%, 123/305), 2 times (53.77%, 164/305), and ≥3 times (5.90%, 18/305).Univariate linear regression analysis showed that brushing twice daily was negatively correlated with EOS%, EOS#, BAS%, and BAS#(all β > 0, all P < 0.05), and positively correlated with SOD and IGF-1(both β < 0, P=0.028, P=0.007). Brushing three or more times daily was negatively correlated with UA[β(95% CI): -0.16(-0.27~0.04), P=0.008]. Multivariate linear regression analysis showed that brushing twice daily was negatively correlated with BAS%(β < 0, P=0.042) and positively correlated with SOD and IGF-1(both β > 0, P=0.036, P=0.012), while brushing three or more times daily was negatively correlated with UA(β < 0, P=0.026). Subgroup analysis revealed that in male adolescents, brushing twice daily was positively correlated with IGF-1(β > 0, P=0.044), and in female adolescents, brushing three or more times daily was negatively correlated with UA(β < 0, P=0.014).
The adolescent tooth brushing frequency correlates with several blood indicators affecting general health, suggesting that there may be a potential association between oral health and general health.
| [1] |
Tonetti M S, Jepsen S, Jin L J, et al. Impact of the global burden of periodontal diseases on health, nutrition and wellbeing of mankind: a call for global action[J]. J Clin Periodontol, 2017, 44(5): 456-462. DOI: 10.1111/jcpe.12732
|
| [2] |
De Oliveira C, Watt R, Hamer M. Toothbrushing, inflammation, and risk of cardiovascular disease: results from Scottish Health Survey[J]. BMJ, 2010, 340: c2451. DOI: 10.1136/bmj.c2451
|
| [3] |
Karlsson H, Ahlborg B, Dalman C, et al. Association between erythrocyte sedimentation rate and IQ in Swedish males aged 18-20[J]. Brain Behav Immun, 2010, 24(6): 868-873. DOI: 10.1016/j.bbi.2010.02.009
|
| [4] |
邹聚芬, 毕小琴. 成都市社区成年居民口腔健康现状调查及影响因素分析[J]. 中华现代护理杂志, 2022, 28(2): 177-183. DOI: 10.3760/cma.j.cn115682-20210715-03142
Zou J F, Bi X Q. Oral health status and influencing factors of adult residents in Chengdu communities[J]. Chin J Mod Nurs, 2022, 28(2): 177-183. DOI: 10.3760/cma.j.cn115682-20210715-03142
|
| [5] |
Furuta M, Takeuchi K, Takeshita T, et al. Longitudinal associations of toothbrushing with obesity and hyperglycemia[J]. J Epidemiol, 2020, 30(12): 556-565. DOI: 10.2188/jea.JE20190165
|
| [6] |
Matsui S, Kajikawa M, Maruhashi T, et al. Decreased frequency and duration of tooth brushing is a risk factor for endothelial dysfunction[J]. Int J Cardiol, 2017, 241: 30-34. DOI: 10.1016/j.ijcard.2017.03.049
|
| [7] |
Tanaka A, Takeuchi K, Furuta M, et al. Relationship of toothbrushing to metabolic syndrome in middle-aged adults[J]. J Clin Periodontol, 2018, 45(5): 538-547. DOI: 10.1111/jcpe.12876
|
| [8] |
Jackson D J, Akuthota P, Roufosse F. Eosinophils and eosinophilic immune dysfunction in health and disease[J]. Eur Respir Rev, 2022, 31(163): 210150. DOI: 10.1183/16000617.0150-2021
|
| [9] |
Nishikawa D, Suzuki H, Beppu S, et al. Eosinophil prognostic scores for patients with head and neck squamous cell carcinoma treated with nivolumab[J]. Cancer Sci, 2021, 112(1): 339-346. DOI: 10.1111/cas.14706
|
| [10] |
张侃, 陈利红, 阮土耿. 外周血嗜酸性粒细胞检测对口腔鳞状细胞癌术后的预后意义[J]. 口腔医学, 2016, 36(6): 546-549. https://www.cnki.com.cn/Article/CJFDTOTAL-KQYX201606018.htm
Zhang K, Chen L H, Ruan T G. The prognostic significance of peripheral blood eosinophilia in oral squamous cell carcinoma after surgery[J]. Stomatology, 2016, 36(6): 546-549. https://www.cnki.com.cn/Article/CJFDTOTAL-KQYX201606018.htm
|
| [11] |
Chen K, Hao Y J, Guzmán M, et al. Antibody-mediated regulation of basophils: emerging views and clinical implications[J]. Trends Immunol, 2023, 44(6): 408-423. DOI: 10.1016/j.it.2023.04.003
|
| [12] |
Cromheecke J L, Nguyen K T, Huston D P. Emerging role of human basophil biology in health and disease[J]. Curr Allergy Asthma Rep, 2014, 14(1): 408. DOI: 10.1007/s11882-013-0408-2
|
| [13] |
Zheng M L, Liu Y T, Zhang G F, et al. The applications and mechanisms of superoxide dismutase in medicine, food, and cosmetics[J]. Antioxidants (Basel), 2023, 12(9): 1675. DOI: 10.3390/antiox12091675
|
| [14] |
Kwon M J, Kim B, Lee Y S, et al. Role of superoxide dismutase 3 in skin inflammation[J]. J Dermatol Sci, 2012, 67(2): 81-87. DOI: 10.1016/j.jdermsci.2012.06.003
|
| [15] |
Nguyen N H, Tran G B, Nguyen C T. Anti-oxidative effects of superoxide dismutase 3 on inflammatory diseases[J]. J Mol Med (Berl), 2020, 98(1): 59-69. DOI: 10.1007/s00109-019-01845-2
|
| [16] |
Sabogal Piñeros Y S, Bal S M, Van De Pol M A, et al. Anti-IL-5 in mild asthma alters rhinovirus-induced macrophage, B-cell, and neutrophil responses (material). A placebo-controlled, double-blind study[J]. Am J Respir Crit Care Med, 2019, 199(4): 508-517. DOI: 10.1164/rccm.201803-0461OC
|
| [17] |
Fulkerson P C, Rothenberg M E. Targeting eosinophils in allergy, inflammation and beyond[J]. Nat Rev Drug Discov, 2013, 12(2): 117-129. DOI: 10.1038/nrd3838
|
| [18] |
Barnes N C, Sharma R, Lettis S, et al. Blood eosinophils as a marker of response to inhaled corticosteroids in COPD[J]. Eur Respir J, 2016, 47(5): 1374-1382. DOI: 10.1183/13993003.01370-2015
|
| [19] |
Mauras N, Ross J, Mericq V. Management of growth disorders in puberty: GH, GnRHa, and aromatase inhibitors: a clinical review[J]. Endocr Rev, 2023, 44(1): 1-13. DOI: 10.1210/endrev/bnac014
|
| [20] |
罗洁, 许辉. 牙周炎与血尿酸水平的相关性研究[J]. 江西医药, 2014, 49(11): 1290-1291. DOI: 10.3969/j.issn.1006-2238.2014.11.069
Luo J, Xu H. A study on the correlation between periodontitis and blood uric acid levels[J]. Jiangxi Med J, 2014, 49(11): 1290-1291. DOI: 10.3969/j.issn.1006-2238.2014.11.069
|
| [21] |
Wang Y T, Charchar F J. Establishment of sex difference in circulating uric acid is associated with higher testosterone and lower sex hormone-binding globulin in adolescent boys[J]. Sci Rep, 2021, 11(1): 17323. DOI: 10.1038/s41598-021-96959-4
|
| [22] |
Juul A, Dalgaard P, Blum W F, et al. Serum levels of insulin-like growth factor (IGF)-binding protein-3(IGFBP-3) in healthy infants, children, and adolescents: the relation to IGF-Ⅰ, IGF-Ⅱ, IGFBP-1, IGFBP-2, age, sex, body mass index, and pubertal maturation[J]. J Clin Endocrinol Metab, 1995, 80(8): 2534-2542.
|
| [23] |
Zierk J, Arzideh F, Rechenauer T, et al. Age- and sex-specific dynamics in 22 hematologic and biochemical analytes from birth to adolescence[J]. Clin Chem, 2015, 61(7): 964-973. DOI: 10.1373/clinchem.2015.239731
|
| [24] |
Martínez De Toda I, González-Sánchez M, Díaz-Del Cerro E, et al. Sex differences in markers of oxidation and inflammation. Implications for ageing[J]. Mech Ageing Dev, 2023, 211: 111797. DOI: 10.1016/j.mad.2023.111797
|
| [25] |
Ohlsson C, Jansson J O, Isaksson O. Effects of growth hormone and insulinlike growth factor-I on body growth and adult bone metabolism[J]. Curr Opin Rheumatol, 2000, 12(4): 346-348. DOI: 10.1097/00002281-200007000-00019
|
| [26] |
Dyer A H, Vahdatpour C, Sanfeliu A, et al. The role of Insulin-Like Growth Factor 1(IGF-1) in brain development, maturation and neuroplasticity[J]. Neuroscience, 2016, 325: 89-99. DOI: 10.1016/j.neuroscience.2016.03.056
|
| [27] |
郑婵娟. 儿童青少年血清IGF-1及IGFBP-3的正常参考值研究[J]. 医学信息, 2019, 32(18): 178-180. DOI: 10.3969/j.issn.1006-1959.2019.18.063
Zheng C J. Study on normal reference values of serum IGF-1 and IGFBP-3 in children and adolescents[J]. J Med Inf, 2019, 32(18): 178-180. DOI: 10.3969/j.issn.1006-1959.2019.18.063
|
| [28] |
袁仙仙, 阳洪波, 朱惠娟, 等. 胰岛素样生长因子-1测定方法及参考值范围[J]. 协和医学杂志, 2020, 11(4): 472-478. DOI: 10.3969/j.issn.1674-9081.2020.04.020
Yuan X X, Yang H B, Zhu H J, et al. Measurement and the reference range of serum insulin-like growth factor-1[J]. Med J PUMCH, 2020, 11(4): 472-478. DOI: 10.3969/j.issn.1674-9081.2020.04.020
|
| [29] |
Borghi C, Agabiti-Rosei E, Johnson R J, et al. Hyperuricaemia and gout in cardiovascular, metabolic and kidney disease[J]. Eur J Intern Med, 2020, 80: 1-11. DOI: 10.1016/j.ejim.2020.07.006
|
| [30] |
Borghi C, Agnoletti D, Cicero A F G, et al. Uric acid and hypertension: a review of evidence and future perspectives for the management of cardiovascular risk[J]. Hyperten-sion, 2022, 79(9): 1927-1936. DOI: 10.1161/HYPERTENSIONAHA.122.17956
|
| [31] |
徐娟. 性别差异对血尿酸水平影响的研究进展[C]//2017年第五次世界中西医结合大会论文摘要集(上册). 北京: 中国中西医结合学会, 2017: 829.
Xu J. Research progress on the impact of gender differences on blood uric acid levels[C]//Summary Collection of Papers at the 5th World Congress of Integrated Traditional Chinese and Western Medicine in 2017(Volume 1). Beijing: Chinese Association of Integrative Medicine, 2017: 829.
|
| [32] |
徐静. 血清尿酸、高尿酸血症与牙周炎的关联性研究: 基于NHANES数据库的横断面研究[D]. 长春: 吉林大学, 2023.
Xu J. Association between serum uric acid, hyperuricemia and periodontitis: a cross-sectional study using NHANES data[D]. Changchun: Jilin University, 2023.
|
| [1] | SUN Jianhua, LUO Hongbo, LI Zunzhu, LU Meishan, LIAN Hui, WANG Xiaoting, Critical Care Ultrasound Study Group. Cognition and Practice of Doctor-Nurse Integration Construction in the Department of Critical Care Medicine[J]. Medical Journal of Peking Union Medical College Hospital, 2024, 15(3): 518-521. DOI: 10.12290/xhyxzz.2024-0116 |
| [2] | CUI Jing, DU Hanze, ZHAI Wenhao, WEN Linlin, HUANG Lei, CHEN Shi, LI Daowei, PAN Hui. Oral Proactive Healthcare and Obesity[J]. Medical Journal of Peking Union Medical College Hospital, 2024, 15(2): 450-455. DOI: 10.12290/xhyxzz.2024-0071 |
| [3] | ZHANG Wenjing, ZHU Tienan, LI Kuixing. Oral Anticoagulation Therapy Increased the Incidence of Abnormal Uterine Bleeding in Patients with Thrombophilia: A Single-center Retrospective Study[J]. Medical Journal of Peking Union Medical College Hospital, 2024, 15(1): 117-123. DOI: 10.12290/xhyxzz.2023-0265 |
| [4] | KE Dandan, JIA Nan, CUI Puan, HE Zhong. Current Situation, Challenges and Suggestions for the Development of Primary Health Care Services in China in the Post Pandemic Era[J]. Medical Journal of Peking Union Medical College Hospital, 2024, 15(1): 45-51. DOI: 10.12290/xhyxzz.2023-0290 |
| [5] | MA Yanru, NIU Na, CAO Xinxin, LI Yi, JING Hongli, LIU Yu, CHEN Libo. Characteristics of 99mTc-MDP Whole-body Bone Scintigraphy in Erdheim-Chester Disease[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(4): 781-786. DOI: 10.12290/xhyxzz.2023-0162 |
| [6] | LI Xin, LIU Lu, LIU Zhihong, ZHAO Zhihui, LUO Qin, ZHAO Qing. Progress in the Application of Oral Anticoagulants in Patients with Non-valvular Atrial Fibrillation and Chronic Renal Insufficiency[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(2): 302-307. DOI: 10.12290/xhyxzz.2021-0256 |
| [7] | WANG Yuanyuan, XIE Lili, GUO Dongmei, GUO Qiuyun, QUAN Tao, XIE Qi, BAO Baicheng. A Sampling Survey of Oral Health Status among the 12-year-old Children in Hainan Province (2015—2016)[J]. Medical Journal of Peking Union Medical College Hospital, 2021, 12(3): 353-358. DOI: 10.12290/xhyxzz.20200279 |
| [8] | Zheng Wan, Yongle Li. The Status of Warfarin in the Era of Novel Oral Anticoagulants[J]. Medical Journal of Peking Union Medical College Hospital, 2018, 9(2): 108-111. DOI: 10.3969/j.issn.1674-9081.2018.02.003 |
| [9] | Rong-li YANG, Xiu-kai CHEN, Xiao-ting WANG, Da-wei LIU. Critical Care Blood Purification and Integration[J]. Medical Journal of Peking Union Medical College Hospital, 2017, 8(6): 375-380. DOI: 10.3969/j.issn.1674-9081.2017.06.011 |
| [10] | Li-an HOU, Ling QIU, Qian DI, Xiu-zhi GUO, Hong-jie XIE, Peng-chang LI, Kai WANG, Xin-qi CHENG, Li LIU. Performance Verification of CardioChek PA Lipid Point-of-care Devices[J]. Medical Journal of Peking Union Medical College Hospital, 2014, 5(3): 283-289. DOI: 10.3969/j.issn.1674-9081.2014.03.008 |
Supported by: Beijing Renhe Information Technology Co., Ltd. 
Submit
Review
Office
Email Alert
RSS
DownLoad: