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Volume 15 Issue 4
Jul.  2024
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Abstract
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HAN Xu, YANG Yihong, JIANG Hui, LIU Yecheng. Risk Factors of Capillary Leak Syndrome in Patients with Acute Organophosphorus Pesticide Poisoning[J]. Medical Journal of Peking Union Medical College Hospital, 2024, 15(4): 855-861. DOI: 10.12290/xhyxzz.2023-0659
Citation: HAN Xu, YANG Yihong, JIANG Hui, LIU Yecheng. Risk Factors of Capillary Leak Syndrome in Patients with Acute Organophosphorus Pesticide Poisoning[J]. Medical Journal of Peking Union Medical College Hospital, 2024, 15(4): 855-861. DOI: 10.12290/xhyxzz.2023-0659
shu

Risk Factors of Capillary Leak Syndrome in Patients with Acute Organophosphorus Pesticide Poisoning

  • 1.

    Department of Emergency, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

  • 2.

    State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

  • 3.

    Department of Emergency, Fuyang People's Hospital, Fuyang, Anhui 236000, China

Funds: 

Fuyang Key Research and Development Plan Clinical Medical Research Transformation Project FYZDYF2023LCYX034

More Information
  • Corresponding author:

    LIU Yecheng, E-mail: ptcaliu@sina.com

  • Received Date: December 26, 2023
  • Accepted Date: April 10, 2024
  • Available Online: April 24, 2024
  • Publish Date: April 23, 2024
  • Issue Publish Date: July 29, 2024
    Graphical Abstract
    • Abstract
  • Objective 

    To explore the risk factors of capillary leakage syndrome in patients with acute organophosphorus pesticide poisoning (AOPP), in order to provide reference for clinical screening and intervention timing.

    Methods 

    The clinical manifestations, auxiliary examination and prognosis of AOPP patients admitted in Fuyang People's Hospital from November 2020 to June 2022 were prospectively analyzed, and the patients were divided into non-CLS group and CLS group based on the presence or absence of capillary leak syndrome (CLS). Patients were admitted to hospital as the starting point, and death or discharge as the endpoint. Multiple Logistic regression analysis was used to explore the risk factors of AOPP complicated with CLS.

    Results 

    A total of 38 AOPP patients were included, of which 17 (44.7%) were complicated with CLS. There were statistical differences in age (P=0.015), blood concentration of dichlorvos (P=0.001), blood concentration of dipterex(P < 0.001), creatinine (P < 0.001) and APACHEⅡ score (P < 0.001) between non-CLS group and CLS group. Multivariate Logistic regression analysis showed that blood concentration of dipterex ≥0.44 μg/mL and APACHEⅡ score≥10.5 were independent risk factors for AOPP complicated with CLS. The mortality rate of CLS group was higher than that of CLS group (P < 0.001).

    Conclusions 

    Patients with AOPP are more likely to be complicated by CLS, and the mortality rate is higher. High-risk patients can be identified early by dipterex blood concentration and APACHE Ⅱ score, and early intervention can be carried out to improve the prognosis of patients.

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