Email Alert RSS
Turn off MathJax
Article Contents
Article Navigation >  Medical Journal of Peking Union Medical College Hospital  > 2024  > 
LIU Wei, XU Xiaohan, YU Xuerong. Association between Preoperative Hypoalbuminemia and Risk of Perioperative Allogeneic red Blood Cell in Patients Undergoing Cytoreductive Surgery for Ovarian Cancer: A Single-Center Retrospective Cohort Study[J]. Medical Journal of Peking Union Medical College Hospital. doi: 10.12290/xhyxzz.2023-0544
Citation: LIU Wei, XU Xiaohan, YU Xuerong. Association between Preoperative Hypoalbuminemia and Risk of Perioperative Allogeneic red Blood Cell in Patients Undergoing Cytoreductive Surgery for Ovarian Cancer: A Single-Center Retrospective Cohort Study[J]. Medical Journal of Peking Union Medical College Hospital. doi: 10.12290/xhyxzz.2023-0544
shu

Association between Preoperative Hypoalbuminemia and Risk of Perioperative Allogeneic red Blood Cell in Patients Undergoing Cytoreductive Surgery for Ovarian Cancer: A Single-Center Retrospective Cohort Study

doi: 10.12290/xhyxzz.2023-0544

  • Department of Anesthesiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

Funds:

National Natural Science Foundation of China (72304281)

  • Received Date: 2023-11-16
  • Accepted Date: 2023-11-29
    • Available Online: 2024-04-19
    Abstract
  • Objective To analyze the correlation between preoperative hypoproteinemia and the risk of perioperative allogeneic erythrocyte transfusion in ovarian cancer patients undergoing cytoreductive surgery. Methods Ovarian cancer patients who underwent cytoreductive surgery at Peking Union Medical College Hospital from January 2014 to December 2018 were retrospectively included. Clinical data such as the patients' general information, preoperative plasma albumin, American Society of Anesthesiologists classification, intraoperative bleeding volume, operation time, perioperative (intraoperative and within 3 d postoperatively) allogeneic red blood cell transfusion were collected, and the correlation between preoperative hypoproteinemia (plasma albumin＜35g/L) and the risk of allogeneic red blood cell infusion was analyzed by using multivariate Logistic regression. Results A total of 1001 ovarian cancer patients who met the inclusion and exclusion criteria were enrolled, of which 64 (6.4%) had preoperative hypoproteinemia and 481 (48.1%) received perioperative allogeneic red blood cell transfusion. The rate of perioperative allogeneic red blood cell transfusion was higher in the patients with hypoproteinemia than in those without hypoproteinemia [84.4% (54/64) vs. 45.6% (427/937), P＜0.001]. Multivariate Logistic regression analysis corrected for confounders such as American Society of Anesthesiologists classification, intraoperative bleeding volume, and operative time found that preoperative hypoproteinemia was significantly associated with the risk of perioperative allogeneic red blood cell transfusion (OR=5.68, 95% CI: 2.56-13.57, P＜0.001). Conclusion : Preoperative hypoalbuminemia could be associated with the increased risk of perioperative transfusion in patients undergoing cytoreductive surgery for ovarian cancer.
    • FullText(HTML)
  • loading
    • References(29)
  • [1] Prescott L S, Aloia T A, Brown A J, et al. Perioperative blood transfusion in gynecologic oncology surgery:analysis of the National Surgical Quality Improvement Program Database[J]. Gynecol Oncol, 2015, 136(1):65-70.
    [2] Weber R S, Jabbour N, Martin R C G 2nd. Anemia and transfusions in patients undergoing surgery for cancer[J]. Ann Surg Oncol, 2008, 15(1):34-45.
    [3] Carson J L, Stanworth S J, Roubinian N, et al. Transfusion thresholds and other strategies for guiding allogeneic red blood cell transfusion[J]. Cochrane Database Syst Rev, 2016, 10(10):CD002042.
    [4] Bolton-Maggs P H B. SHOT conference report 2016:serious hazards of transfusion-human factors continue to cause most transfusion-related incidents[J]. Transfus Med, 2016, 26(6):401-405.
    [5] Goldman M, Webert K E, Arnold D M, et al. Proceedings of a consensus conference:towards an understanding of TRALI[J]. Transfus Med Rev, 2005, 19(1):2-31.
    [6] 李鑫,张国炜,万江涛,等.术前低白蛋白血症与后路腰椎融合术后不良结局发生率的相关性[J].中国临床解剖学杂志, 2022, 40(4):485-490.

    Li X, Zhang G W, Wan J T, et al. Correlation between preoperative hypoalbuminemia and prevalence of adverse events after posterior lumbar interbody fusion[J]. Chin J Clin Anat, 2022, 40(4):485-490.
    [7] Phan K, Ranson W, White S J W, et al. Thirty-day perioperative complications, prolonged length of stay, and readmission following elective posterior lumbar fusion associated with poor nutritional status[J]. Global Spine J, 2019, 9(4):417-423.
    [8] Kim K, Seo H, Chin J H, et al. Preoperative hypoalbuminemia and anemia as predictors of transfusion in radical nephrectomy for renal cell carcinoma:a retrospective study[J]. BMC Anesthesiol, 2015, 15:103.
    [9] De la Garza Ramos R, Gelfand Y, Benton J A, et al. Rates, risk factors, and complications of red blood cell transfusion in metastatic spinal tumor surgery:an analysis of a prospective multicenter surgical database[J]. World Neurosurg, 2020, 139:e308-e315.
    [10] Conrad L B, Awdeh H, Acosta-Torres S, et al. Pre-operative core muscle index in combination with hypoalbuminemia is associated with poor prognosis in advanced ovarian cancer[J]. J Surg Oncol, 2018, 117(5):1020-1028.
    [11] Bohl D D, Shen M R, Kayupov E, et al. Hypoalbuminemia independently predicts surgical site infection, pneumonia, length of stay, and readmission after total joint arthroplasty[J]. J Arthroplasty, 2016, 31(1):15-21.
    [12] 胡俊,袁瑞,王琴.术后低蛋白血症与补充人血白蛋白对卵巢癌手术切口愈合不良的影响[J].重庆医学, 2023, 52(15):2320-2325.

    Hu J, Yuan R, Wang Q. Effect of postoperative hypoproteinemia and supplement of human serum albumin on the development of poor wound healing following ovarian cancer surgery[J]. Chongqing Med J, 2023, 52(15):2320-2325.
    [13] 陈月芬,马玉燕.低蛋白血症与子痫前期的发生和发展[J].中国计划生育和妇产科, 2021, 13(2):10-12.

    Chen Y F, Ma Y Y. Hypoproteinemia and the occurrence and development of preeclampsia[J]. Chin J Family Plann Gynecotokol, 2021, 13(2):10-12.
    [14] Newman J M, Sodhi N, Khlopas A, et al. Malnutrition increases the 30-day complication and re-operation rates in hip fracture patients treated with total hip arthroplasty[J]. Hip Int, 2020, 30(5):635-640.
    [15] Kamath A F, Ong K L, Lau E, et al. Quantifying the burden of revision total joint arthroplasty for periprosthetic infection[J]. J Arthroplasty, 2015, 30(9):1492-1497.
    [16] 戴仲,李莉,严静.白蛋白用于液体复苏的研究进展[J].实用医学杂志, 2015, 31(20):3442-3443.

    Dai Z, Li L, Yan J. Research progress on albumin for liquid resuscitation[J]. J Pract Med, 2015, 31(20):3442-3443.
    [17] Vincent J L, Dubois M J, Navickis R J, et al. Hypoalbuminemia in acute illness:is there a rationale for intervention?A metaanalysis of cohort studies and controlled trials[J]. Ann Surg, 2003, 237(3):319-334.
    [18] 赵滨如,刘惠兰.血浆蛋白测定对评价尿毒症病人营养不良的意义[J].北京医学, 2000, 22(3):168. Zhao B R, Liu H L. The significance of plasma protein measurement in evaluating malnutrition in patients with uremia[J]. Beijing Med J, 2000

    , 22(3):168.
    [19] 张阳,张立志,李放,等.低蛋白血症与高龄患者腰椎融合术后并发症的相关性研究[J].中国骨与关节杂志, 2021, 10(4):244-247.

    Zhang Y, Zhang L Z, Li F, et al. Association between preoperative hypoalbuminemia and complications after posterior lumbar fusion in the elderly[J]. Chin J Bone Joint, 2021, 10(4):244-247.
    [20] 王婷婷,张锦.腹部大手术围手术期低蛋白血症的原因及治疗进展[J].中国医师进修杂志, 2020, 43(6):569-572.

    Wang T T, Zhang J. The causes and treatment progress of perioperative hypoalbuminemia in major abdominal surgery[J]. Chin J Postgrad Med, 2020, 43(6):569-572.
    [21] 王燕.低蛋白血症与复发性脑梗死的相关性研究[J].中西医结合心脑血管病杂志, 2019, 17(2):282-284.

    Wang Y. A study on the correlation between hypoalbuminemia and recurrent cerebral infarction[J]. Chin J Integr Med Cardio-Cerebrovasc Dis, 2019, 17(2):282-284.
    [22] Shah N R, Dumler F. Hypoalbuminaemia——a marker of cardiovascular disease in patients with chronic kidney disease stages II-IV[J]. Int J Med Sci, 2008, 5(6):366-370.
    [23] Staples A O, Greenbaum L A, Smith J M, et al. Association between clinical risk factors and progression of chronic kidney disease in children[J]. Clin J Am Soc Nephrol, 2010, 5(12):2172-2179.
    [24] Inker L A, Coresh J, Levey A S, et al. Estimated GFR, albuminuria, and complications of chronic kidney disease[J]. J Am Soc Nephrol, 2011, 22(12):2322-2331.
    [25] 王元芬,窦莎,朱崇元,等.可吸收防粘连纤维膜对卵巢癌患者术后盆腔淋巴囊肿形成的影响[J].现代妇产科进展, 2022, 31(12):906-910.

    Wang Y F, Dou S, Zhu C Y, et al. Effect of absorbable anti-adhesion fibrous membrane on the incidence of lymphoceles in patients with ovarian cancer[J]. Prog Obstet Gynecol, 2022, 31(12):906-910.
    [26] Dickerson R N, White K G, Curcillo P G 2nd, et al. Resting energy expenditure of patients with gynecologic malignancies[J]. J Am Coll Nutr, 1995, 14(5):448-454.
    [27] Cham S, Chen L, St Clair C M, et al. Development and validation of a risk-calculator for adverse perioperative outcomes for women with ovarian cancer[J]. Am J Obstet Gynecol, 2019, 220(6):571.e1-571.e8.
    [28] Wu Y, Mu J, Cao J, et al. Research status and progress of nutritional support therapy for ovarian cancer[J]. Nutr Cancer, 2022, 74(5):1519-1526.
    [29] 杜权,张华云,汤红英.严重低蛋白血症卵巢癌根治术后诱发急性肺水肿1例[J].陆军军医大学学报, 2000, 22(1):52. Du Q, Zhang H Y, Tang H Y. A case of pulmonary edema induced by sever hypoproteinemia after the radical operation of oophoroma[J]. J Army Med Univ, 2000

    , 22(1):52.
    • Relative Articles(0)
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索
    Get Citation
    PDF
    XML

    Article Metrics

    Article views (18) PDF downloads(0) Cited by()
    Proportional views
    Related
    Links: National Health Commission of the People's Republic of China Chinese Academy of Medical Sciences(CAMS) AMLC Check CNKI Database CNKI Term Online Chinese General Practice
    Address：Room 302,Third Floor,Building 7, No. 1 Shuaifuyuan, Wangfujing, Dongcheng District, Beijing 100730, China
    Tel：010-69154261/4262
    E - mail：medj@pumch.cn
    mjpumch@126.com
    Copyright of website：Editorial Office of Medical Journal of Peking Union Medical College Hospital

    Supported by: Beijing Renhe Information Technology Co. Ltd    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return