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Volume 15 Issue 1
Jan.  2024
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ZHANG Xin, ZHANG Xiao, GUO Yi, FENG Jun, XIAO Zhiyuan, XIE Zhaoxiang, WU Jing, XU Dongrui, WEI Junji, WANG Yu. Successful Treatment of A Patient with Chronic Myeloid Leukemia Complicated by Cerebral Hemorrhage Manifesting as Platelet Abnormal Elevation[J]. Medical Journal of Peking Union Medical College Hospital, 2024, 15(1): 217-222. DOI: 10.12290/xhyxzz.2023-0377
Citation: ZHANG Xin, ZHANG Xiao, GUO Yi, FENG Jun, XIAO Zhiyuan, XIE Zhaoxiang, WU Jing, XU Dongrui, WEI Junji, WANG Yu. Successful Treatment of A Patient with Chronic Myeloid Leukemia Complicated by Cerebral Hemorrhage Manifesting as Platelet Abnormal Elevation[J]. Medical Journal of Peking Union Medical College Hospital, 2024, 15(1): 217-222. DOI: 10.12290/xhyxzz.2023-0377
shu

Successful Treatment of A Patient with Chronic Myeloid Leukemia Complicated by Cerebral Hemorrhage Manifesting as Platelet Abnormal Elevation

  • 1.

    Department of Neurosurgery, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

  • 2.

    Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

Funds: 

National High Level Hospital Clinical Research Funding 2022-PUMCH-C-032

Beijing Tianjin Hebei Basic Research Cooperation Project 19JCZDJC64600(Z)

More Information
  • Corresponding author:

    WEI Junji, E-mail: weijj1999@163.com

    WANG Yu, E-mail: kingrichwy@126.com

  • Received Date: August 14, 2023
  • Accepted Date: October 08, 2023
  • Issue Publish Date: January 29, 2024
    Graphical Abstract
    • Abstract
  • Platelet elevation is a rare manifestation in the peripheral blood of patients with chronic myeloid leukemia (CML). In this paper, we report for the first time a case of CML combined with cerebral hemorrhage manifested by abnormally elevated platelets. The patient had elevated platelets in the peripheral blood, showed normal coagulation function, and underwent intracranial hematoma removal due to cerebral hemorrhage. After the operation, bleeding from the operated area and other systems occurred, and the patient was diagnosed as having accelerated CML after combining bone marrow biopsy and genetic testing. His condition was controlled after administration of flumatinib through a jejunal tube. Based on this patient's experience, the feasibility ofadministering flumatinib via a jejunostomy tube was determined, which is the first report of its kind in China and abroad.This article summarizes the diagnosis and treatment process of this patient, with the aim of providing a warning and reference for clinicians.
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    • References (29)
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