Volume 14 Issue 4
Jul.  2023
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SHI Yue, ZHU Bo, HUANG Yuguang. Excitatory-inhibitory Imbalance and Autism Spectrum Disorder: Mechanism and Treatment Progress[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(4): 844-849. doi: 10.12290/xhyxzz.2023-0174
Citation: SHI Yue, ZHU Bo, HUANG Yuguang. Excitatory-inhibitory Imbalance and Autism Spectrum Disorder: Mechanism and Treatment Progress[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(4): 844-849. doi: 10.12290/xhyxzz.2023-0174

Excitatory-inhibitory Imbalance and Autism Spectrum Disorder: Mechanism and Treatment Progress

doi: 10.12290/xhyxzz.2023-0174

National High Level Hospital Clinical Research Funding 2022-PUMCH-B-119

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  • Corresponding author: ZHU Bo, E-mail: zhubo@pumch.cn
  • Received Date: 2023-04-04
  • Accepted Date: 2023-05-31
  • Publish Date: 2023-07-30
  • Autism spectrum disorder (ASD) is becoming one of the fastest growing neurodevelopmen-tal disorders around the world, yet its clinical treatment still faces challenge due to the heterogeneity in etiology and symptom phenotypes. It is believed that excitatory-inhibitory (E-I) imbalance in the central nervous system may play an important role in the pathogenic mechanisms of ASD. E-I imbalances in synaptic transmission and neural circuits are frequently observed in different animal models of ASD, and the corresponding reversion normalizes the autism-like behaviors in these animals. Some E-I modulators have been tested for their therapeutic potential on ASD patients with encouraging results. This article expounds the mechanism of E-I imbalance in ASD and E-I imbalance regulators treatment progress, to provide new insights on the therapeutic targets for ASD.
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