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Volume 14 Issue 4
Jul.  2023
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LIU Zhikai, CHENG Weishi, WU Wangsuo, LIANG Tianjiao, XING Qingzi, ZHANG Zizhu, LIU Zhibo, LIU Yuanhao, PAN Jianji, ZHU Shaihong, LI Qingnuan, ZHANG Fuquan, QIU Jie, HUO Li. Principles and Clinical Applications of Boron Neutron Capture Therapy[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(4): 698-705. DOI: 10.12290/xhyxzz.2023-0120
Citation: LIU Zhikai, CHENG Weishi, WU Wangsuo, LIANG Tianjiao, XING Qingzi, ZHANG Zizhu, LIU Zhibo, LIU Yuanhao, PAN Jianji, ZHU Shaihong, LI Qingnuan, ZHANG Fuquan, QIU Jie, HUO Li. Principles and Clinical Applications of Boron Neutron Capture Therapy[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(4): 698-705. DOI: 10.12290/xhyxzz.2023-0120
shu

Principles and Clinical Applications of Boron Neutron Capture Therapy

  • 1.

    Department of Radiotherapy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

  • 2.

    School of Nuclear Science and Technology, Lanzhou University, Lanzhou 730000, China

  • 3.

    Institute of High Energy Physics, Chinese Academy of Sciences, Dongguan, Guangdong 100049, China

  • 4.

    Department of Engineering Physics, Tsinghua University, Beijing 100084, China

  • 5.

    Beijing Nuclear Industry Hospital, Beijing 100045, China

  • 6.

    School of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China

  • 7.

    China Boron (Xiamen) Medical Devices Co., Ltd., Xiamen, Fujian 361028, China

  • 8.

    Fujian Medical University, Fuzhou 350122, China

  • 9.

    The Third Xiangya Hospital of Central South University, Changsha 410013, China

  • 10.

    Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China

  • 11.

    Department of Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

More Information
  • Corresponding author:

    HUO Li, E-mail: huoli@pumch.cn

  • Received Date: March 09, 2023
  • Accepted Date: April 02, 2023
  • Available Online: April 03, 2023
  • Issue Publish Date: July 29, 2023
    Graphical Abstract
    • Abstract
  • Boron neutron capture therapy (BNCT) is an advanced radiation therapy technique that is rapidly developing in the field of cancer treatment. This technique, an atomic-level binary targeted therapy, kills cancer cells by causing a 10B(n, α)7Li nuclear reaction within the cancer cells, and its clinical implementation requires professional technology and device support. The core elements of BNCT include appropriate neutron sources and neutron capture drugs. Compared with traditional radiotherapy techniques, BNCT shows outstanding advantages in treating locally recurrent tumors, such as central nervous system tumors and head and neck tumors. Furthermore, it can better protect normal organs, especially for tumors that have already significantly invaded surrounding organs, demonstrating its promising future prospects. This article mainly elaborates on the technical principles, core elements, and clinical applications of BNCT, in hope of providing reference for clinical diagnosis and treatment.
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    • References (44)
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