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Volume 14 Issue 3
May  2023
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LAN Yuming, WANG Fang, ZHANG Jie. Low-grade Myofibroblastic Sarcoma of the Mandible in Children: A Case Report[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(3): 611-616. DOI: 10.12290/xhyxzz.2023-0091
Citation: LAN Yuming, WANG Fang, ZHANG Jie. Low-grade Myofibroblastic Sarcoma of the Mandible in Children: A Case Report[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(3): 611-616. DOI: 10.12290/xhyxzz.2023-0091
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Low-grade Myofibroblastic Sarcoma of the Mandible in Children: A Case Report

  • Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Nanchang University, Nanchang 330006, China

Funds: 

National Natural Science Foundation of China 81960200

National Natural Science Foundation of China 82160184

Natural Science Foudation of Jiangxi Province 20224ACB206023

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  • Corresponding author:

    ZHANG Jie, E-mail: ndyfy02134@ncu.edu.cn

  • Received Date: February 19, 2023
  • Accepted Date: April 23, 2023
  • Issue Publish Date: May 29, 2023
    Graphical Abstract
    • Abstract
  • Low-grade myofibroblastic sarcoma(LGMS) is an extremely rare malignant tumor of myofibroblastic cells that primarily affects the head and neck region. LGMS occurring in the oral cavity is commonly found on the tongue, and those occurring in the jawbone are less common, with only 12 reported cases to date. LGMS is often in adult males but rare in children. This report describes a rare case of LGMS in the mandible of a child who underwent surgical resection. Histopathological examination revealed spindle cell proliferation with invasive growth into surrounding skeletal muscle. Immunohistochemical staining showed positive expression of Vimentin, Calponin, SMA, and Actin, supporting myofibroblastic and smooth muscle differentiation of the tumor and the diagnosis of LGMS. This article, based on this case and relevant literature, discusses the immunological and pathological characteristics, treatment and prognosis of LGMS in the jawbone, in order to enrich clinicians' understanding and improve the diagnosis of this disease.
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    • References (31)
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