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Volume 14 Issue 5
Sep.  2023
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ZHANG Feifei, WANG Qi, LI Shuguang, WANG Zhanwei, LIANG Xinyue, MENG Han, YANG Shuo, WANG Hui. Clinical Resistance of Helicobacter pylori and Its Trend: A 10-year Data Analysis at Peking University People's Hospital[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(5): 1017-1022. DOI: 10.12290/xhyxzz.2023-0063
Citation: ZHANG Feifei, WANG Qi, LI Shuguang, WANG Zhanwei, LIANG Xinyue, MENG Han, YANG Shuo, WANG Hui. Clinical Resistance of Helicobacter pylori and Its Trend: A 10-year Data Analysis at Peking University People's Hospital[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(5): 1017-1022. DOI: 10.12290/xhyxzz.2023-0063
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Clinical Resistance of Helicobacter pylori and Its Trend: A 10-year Data Analysis at Peking University People's Hospital

  • Laboratory Medicine, Peking University People's Hospital, Beijing 100044, China

Funds: 

2022 Beijing Major Epidemic Prevention and Control Key Specialized Medical Laboratory Excellence Project 

More Information
  • Corresponding author:

    WANG Hui, E-mail: whuibj@163.com

  • Received Date: February 07, 2023
  • Accepted Date: June 08, 2023
  • Issue Publish Date: September 29, 2023
    Graphical Abstract
    • Abstract
  •   Objective  To study the resistance of Helicobacter pylori(Hp) isolated from Peking University People's Hospital to commonly used antibiotics, in order to provide basis for clinical rational drug use.
      Methods  The drug susceptibility test data of Hp strains isolated from gastric mucosal biopsy specimens of outpatients in the Department of Gastroenterology, Peking University People's Hospital from May 2011 to December 2021 were retrospectively collected. The drug resistance rate and dual/multiple drug resistance of Hp to amoxicillin, metronidazole, clarithromycin, levofloxacin and tetracycline were statistically analyzed.
      Results  A total of 120 Hp strains isolated from 402 gastric mucosa specimens (120 patients) and cultured positive were included, with a culture positive rate of 29.85%. The resistance rates of Hp to metronidazole (75.0%) and clarithromycin (72.5%) were relatively high, while the resistance rates to levofloxacin (45.8%), amoxicillin (12.5%) and tetracycline (4.2%) were relatively low. The drug resistance of Hp to clarithromycin and amoxicillin was not significantly affected by the age of the patients. The drug resistance rate to metronidazole and levofloxacin increased with the age of the patients, and the drug resistance rate to tetracycline decreased with the age of the patients. The resistance rate of female patients to levofloxacin was higher than that of male patients (56.7% vs. 32.1%, P=0.007). Over time, the resistance rate of Hp to clarithromycin increased gradually, the resistance rate to levofloxacin increased first and then decreased, the resistance rate to metronidazole fluctuated and was high overall, and the resistance rate to amoxicillin and tetracycline was not significantly affected by time and was relatively low overall. No Hp strains resistant to all five kinds of antibiotics were found. Dual drug resistance rate was 25.0%, with the simultaneous resistance of metronidazole and clarithromycin being the most common (20.0%); multiple drug resistance rate was 44.2%, with the simultaneous resistance of metronidazole + clarithromycin + levofloxacin being the most common (32.5%).
      Conclusions  The resistance rate of Hp strains isolated from Peking University People's Hospital to metronidazole, clarithromycin and levofloxacin is high, and multiple drug resistance is serious. When carrying out empirical Hp root therapy in clinic, the drug regimen should be reasonably selected, and drug sensitivity test should be conducted when necessary, so as to guide the formulation of treatment regimen.
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    • References (21)
  • [1]
    de Brito BB, da Silva FAF, Soares AS, et al. Pathogenesis and clinical management of Helicobacter pylori gastric infection[J]. World J Gastroenterol, 2019, 25: 5578-5589. DOI: 10.3748/wjg.v25.i37.5578
    [2]
    Gravina AG, Zagari RM, Musis CD, et al. Helicobacter pylori and extragastric diseases: A review[J]. World J Gastroenterol, 2018, 24: 3204-3221. DOI: 10.3748/wjg.v24.i29.3204
    [3]
    Fischbach W, Malfertheiner P. Helicobacter pylori infection[J]. Dtsch Arztebl Int, 2018, 115: 429-436.
    [4]
    Smyth EC, Nilsson M, Grabsch HI, et al. Gastric cancer[J]. Lancet, 2020, 396: 635-648. DOI: 10.1016/S0140-6736(20)31288-5
    [5]
    胡伏莲, 周殿元. 幽门螺杆菌感染的基础与临床(修订版)[M]. 北京: 中国科学技术出版社, 2002: 240-249.
    [6]
    胡伏莲. 幽门螺杆菌感染的基础与临床[M]. 北京: 中国科学技术出版社, 2009.
    [7]
    Clinical and Laboratory Standards Institute. Methods for Antimicrobial Dilution and Disk Susceptibility Testing of Infrequently Isolated or Fastidious Bacteria[S]. 3rd ed. CLSI guideline M45. Wayne, Hp: Clinical and Laboratory Standards Institute, 2016.
    [8]
    European Committee on Antimicrobial Susceptibility Testing. Breakpoint tables for interpretation of MICs and zone diameters. Version 13.0[EB/OL ]. (2023-01-01)[2023-02-08]. http://www.eucast.org.
    [9]
    李红, 杨天阔, 申亚琳, 等. 幽门螺杆菌药敏检测方法研究进展[J]. 中华医学杂志, 2020, 100: 2393-2396. DOI: 10.3760/cma.j.cn112137-20200525-01648
    [10]
    Wang YK, Kuo FC, Liu CJ, et al. Diagnosis of Helicobacter pylori infection: Current options and developments[J]. World J Gastroenterol, 2015, 21: 11221-11235. DOI: 10.3748/wjg.v21.i40.11221
    [11]
    胡玢婕, 赵付菊, 柴子岚, 等. 上海地区幽门螺杆菌的检出率及耐药性分析[J]. 中国感染与化疗杂志, 2016, 16: 346-352. DOI: 10.16718/j.1009-7708.2016.03.017
    [12]
    Bluemel B, Goelz H, Goldmann B, et al. Antimicrobial resistance of Helicobacter pylori in Germany, 2015 to 2018[J]. Clin Microbiol Infect, 2020, 26: 235-239. DOI: 10.1016/j.cmi.2019.06.007
    [13]
    Cosme A, Torrente Iranzo S, Montes Ros M, et al. Helicobacter pylori antimicrobial resistance during a 5-year period (2013—2017) in northern Spain and its relationship with the eradication therapies[J]. Helicobacter, 2018, 24: e12557.
    [14]
    Gao W, Cheng H, Hu F, et al. The Evolution of Helico-bacter pylori Antibiotics Resistance Over 10 Years in Beijing, China[J]. Helicobacter, 2010, 15: 460-466. DOI: 10.1111/j.1523-5378.2010.00788.x
    [15]
    姜宗丹, 张振玉, 王志, 等. 南京地区幽门螺杆菌耐药现状及近5年变化趋势[J]. 胃肠病学和肝病学杂志, 2020, 29: 168-171. DOI: 10.3969/j.issn.1006-5709.2020.02.010
    [16]
    Li SY, Li J, Dong XH, et al. The effect of previous eradication failure on antibiotic resistance of Helicobacter pylori: A retrospective study over 8 years in Beijing[J]. Helicobacter, 2021, 26: e12804. DOI: 10.1111/hel.12804
    [17]
    孟霞, 刘改芳, 吴婧, 等. 河北地区幽门螺杆菌临床分离株的耐药性分析[J]. 中华医学杂志, 2016, 96: 270-272. https://www.cnki.com.cn/Article/CJFDTOTAL-LCFC201407009.htm
    [18]
    刘军. 699株幽门螺杆菌对常用抗菌药物的耐药情况分析[J]. 中国医院用药评价与分析, 2018, 18: 274-279. https://www.cnki.com.cn/Article/CJFDTOTAL-YYPF201802041.htm
    [19]
    夏宁宁, 黄丽静, 吴以龙, 等. 福建省闽东地区幽门螺杆菌感染及耐药性分析[J]. 临床内科杂志, 2021, 38: 738-741. https://www.cnki.com.cn/Article/CJFDTOTAL-LCLZ202111007.htm
    [20]
    吴芳草, 王琼, 朱键, 等. 贵阳地区351株幽门螺杆菌药物敏感性及pj6Ip 1多样性分析[J]. 中国人兽共患病学报, 2019, 35: 7587-593. https://www.cnki.com.cn/Article/CJFDTOTAL-ZRSZ201907002.htm
    [21]
    中华医学会消化病学分会幽门螺杆菌和消化性溃疡学组, 第五次全国幽门螺杆菌感染处理共识报告[J]. 胃肠病学, 2017, 22: 346-360.
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