ZHANG Chenxi, ZHANG Zhiqiao, XU Kaifeng, LONG Qin, ZHANG Xiao, YANG Zhikun, DAI Rongping. The Application of Ultra-wide-field Scanning Laser Ophthalmoscopy in the Detection of Tuberous Sclerosis Complex-associated Retinal Astrocytic Hamartomas[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(2): 328-333. doi: 10.12290/xhyxzz.2022-0476
Citation:
ZHANG Chenxi, ZHANG Zhiqiao, XU Kaifeng, LONG Qin, ZHANG Xiao, YANG Zhikun, DAI Rongping. The Application of Ultra-wide-field Scanning Laser Ophthalmoscopy in the Detection of Tuberous Sclerosis Complex-associated Retinal Astrocytic Hamartomas[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(2): 328-333. doi: 10.12290/xhyxzz.2022-0476
ZHANG Chenxi, ZHANG Zhiqiao, XU Kaifeng, LONG Qin, ZHANG Xiao, YANG Zhikun, DAI Rongping. The Application of Ultra-wide-field Scanning Laser Ophthalmoscopy in the Detection of Tuberous Sclerosis Complex-associated Retinal Astrocytic Hamartomas[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(2): 328-333. doi: 10.12290/xhyxzz.2022-0476
Citation:
ZHANG Chenxi, ZHANG Zhiqiao, XU Kaifeng, LONG Qin, ZHANG Xiao, YANG Zhikun, DAI Rongping. The Application of Ultra-wide-field Scanning Laser Ophthalmoscopy in the Detection of Tuberous Sclerosis Complex-associated Retinal Astrocytic Hamartomas[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(2): 328-333. doi: 10.12290/xhyxzz.2022-0476
The Application of Ultra-wide-field Scanning Laser Ophthalmoscopy in the Detection of Tuberous Sclerosis Complex-associated Retinal Astrocytic Hamartomas
Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
2.
Key laboratory of Ocular Fundus Diseases, Chinese Academy of Medical Sciences, Beijing 100730, China
3.
Department of Pulmonary and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
4.
State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
Funds:
National High Level Hospital Clinical Research Funding2022-PUMCH-A-196
National Key Research and Development Program of China2016YFC0901502
National Natural Science Foundation of ChinaU20A20341
Objective To evaluate the clinical value of ultra-wide-field scanning laser ophthalmology(UWF-SLO) in tuberous sclerosis complex (TSC)-associated retinal astrocytic hamartoma (RAH) by comparing the detection rate of RAH lesions between UWF-SLO and traditional color fundus photography (CFP).Methods The clinical data of patients with established TSC-associated RAH diagnosis by the Department of Internal Medicine and Ophthalmology of Peking Union Medical College Hospital from October 2018 to March 2021 were retrospectively reviewed. The detection rate of TSC-associated RAH lesions between 9-fixation-point CFP and UWF-SLO was compared with fundoscopic recordings as the reference standard. The factors that may affect the detection of lesions were analyzed.Results A total of 24 patients with TSC-associated RAH were included in this study. UWF-SLO (composed pseudocolor dual-channel images) performed better than 9-fixation-point CFP in the identification of TSC-associated RAH lesions[98.6%(138/140)vs. 65.7%(92/140), P < 0.001], especially for RAH lesions located in the mid and far peripheral retina (P < 0.001). In UWF-SLO, red-channel (633 nm) images showed significantly lower detection rate than green-channel (532 nm) [52.1% (73/140) vs. 98.6% (138/140), P < 0.001] and composed dual-channel images[52.1%(73/140) vs. 98.6%(138/140), P < 0.001]. Undetected RAH lesions in red-channel UWF-SLO images were all type 1 RAH, and the lession thickness was significantly higher in the detected group than that in the undetected group [(527.3±134.7)μm vs. (389.7±76.6)μm, P < 0.001], while the location and retinal involving depth of type 1 RAH were not significantly different(P=0.812, P=1.000).Conclusions Compared to CFP, UWF-SLO may be associated with higher detection rate of TSC-associated RAH and could be applied to the evaluation of TSC-associated RAH.
Zhang C, Xu K, Long Q, et al. Clinical features and optical coherence tomography findings of retinal astrocytic hamartomas in Chinese patients with tuberous sclerosis complex[J]. Graefes Arch Clin Exp Ophthalmol, 2020, 258: 887-892. doi: 10.1007/s00417-019-04476-y
[3]
Shields J, Eagle R, Shields C, et al. Aggressive retinal astrocytomas in four patients with tuberous sclerosis complex[J]. Trans Am Ophthalmol Soc, 2004, 102: 139-147.
[4]
Bernardes R, Serranho P, Lobo C. Digital ocular fundus imaging: a review[J]. Ophthalmologica, 2011, 226: 161-181. doi: 10.1159/000329597
[5]
Carles G, Muyo G, van Hemert J, et al. Combined high contrast and wide field of view in the scanning laser ophthalmoscope through dual detection of light paths[J]. J Biomed Opt, 2017, 22: 1-10.
[6]
Kanclerz P, Tuuminen R, Khoramnia R. Imaging Modalities Employed in Diabetic Retinopathy Screening: A Review and Meta-Analysis[J]. Diagnostics, 2021, 11: 1802. doi: 10.3390/diagnostics11101802
[7]
Turczyńska M, Krajewski P, Brydak-Godowska J. Wide-Field Fluorescein Angiography in the Diagnosis and Management of Retinal Vein Occlusion: A Retrospective Single-Center Study[J]. Med Sci Monit, 2021, 27: e927782.
[8]
Abadia B, Desco M, Mataix J, et al. Non-Mydriatic Ultra-Wide Field Imaging Versus Dilated Fundus Exam and Intraoperative Findings for Assessment of Rhegmatogenous Retinal Detachment[J]. Brain Sci, 2020, 10: 521. doi: 10.3390/brainsci10080521
[9]
Oishi A, Hidaka J, Yoshimura N. Quantification of the image obtained with a wide-field scanning ophthalmoscope[J]. Invest Ophthalmol Vis Sci, 2014, 55: 2424-2431. doi: 10.1167/iovs.13-13738
[10]
Gomez MR. Tuberous sclerosis complex[M]. New York: Oxford University Press, 1999: 145-159.
Sherman J KG, Jones W, Nath S, et al. Panoramic Ophthalmoscopy: Optomap Images and Interpretation[M]. 1st ed. New Jersey: Slack Incorporated, 2007.
[13]
Nagiel A, Lalane RA, Sadda SR, et al. ULTRA-WIDEFIELD FUNDUS IMAGING: A Review of Clinical Applications and Future Trends[J]. Retina, 2016, 36: 660-678.