A Case of Primary Hepatic Neuroendocrine Tumor with Skin Lump, Rash and Bone Pain as First Symptoms

Neuroendocrine tumors(NETs) commonly occur in organs such as the gastrointestinal tract and pancreas, with the liver being the most common site of metastasis. Primary hepatic neuroendocrine tumors(PHNETs) originating from the liver are exceedingly rare. Herein, we report a case of PHNETs in a patient who presented initially with skin nodules, rash, and bone pain, followed by hyperglycemia and hypoproteinemia. Imaging studies revealed hepatic lesions, and the patient was ultimately diagnosed with PHNETs using ¹⁸F-OCT combined with ¹⁸F-FDG PET/CT and histopathology. The case not only presented a diagnostic challenge, but also exhibited rapid progression involving multiple systems. The experience gained in the diagnosis and treatment of this case may improve clinical awareness of NETs.