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Volume 13 Issue 3
May  2022
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Article Navigation >  Medical Journal of Peking Union Medical College Hospital  > 2022  >  13(3): 363-369
LONG Kai, CAO Pei, JI Tianjiao. Progress of Drug Controlled Release Systems for Local Anesthesia[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(3): 363-369. doi: 10.12290/xhyxzz.2022-0141
Citation: LONG Kai, CAO Pei, JI Tianjiao. Progress of Drug Controlled Release Systems for Local Anesthesia[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(3): 363-369. doi: 10.12290/xhyxzz.2022-0141
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Progress of Drug Controlled Release Systems for Local Anesthesia

doi: 10.12290/xhyxzz.2022-0141
  • 1.

    CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China

  • 2.

    Hubei Key Laboratory of Polymer Materials, Hubei University, Wuhan 430062, China

Funds:  Financial Support of CAS
More Information
  • Corresponding author: JI Tianjiao, E-mail: jitj@nanoctr.cn
  • Received Date: 2022-03-23
  • Accepted Date: 2022-04-18
    • Available Online: 2022-04-22
  • Publish Date: 2022-05-30
    Abstract
  • Reducing the drug administration times and prolonging the postoperative analgesia duration are important requirements of clinical local anesthesia. However, both local anesthetics currently used in the clinic and potentially new anesthetic drugs such as biological toxins have limited pharmaceutical effect. Biomaterials such as liposomes and polymeric microspheres can be designed to load local anesthetics to achieve a prolonged duration and on-demand drug release, accordingly satisfying clinical needs. In this review, we briefly summarized the recent developments in the design of drug delivery systems for controlled release of local anesthetics, and introduced the design principle, the function of several representative drug controlled release systems, and their applications in local anesthesia. We also discussed the challenges and future perspectives in this field.
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