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Volume 13 Issue 2
Mar.  2022
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Abstract
References
Chinese Society of Nuclear Medicine, Chinese Society of Molecular Imaging in Chinese Biophysical Society. Expert Consensus on Clinical Application of Integrin RGD Receptor Imaging (2022)[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(2): 227-234. DOI: 10.12290/xhyxzz.2022-0089
Citation: Chinese Society of Nuclear Medicine, Chinese Society of Molecular Imaging in Chinese Biophysical Society. Expert Consensus on Clinical Application of Integrin RGD Receptor Imaging (2022)[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(2): 227-234. DOI: 10.12290/xhyxzz.2022-0089
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Expert Consensus on Clinical Application of Integrin RGD Receptor Imaging (2022)

Funds: 

National Natural Science Foundation of China 81871392

CAMS Innovation Fund for Medical Sciences 2021-I2M-1-016

The Capital Health Development Scientific Research Project 2018-1-4011

Emergency Key Program of Guangzhou Laboratory EKPG21-16

CAMS Clinical and Translational Medicine Research Fund 2019XK320032

More Information

  • Corresponding authors: ZHU Zhaohui1, 2, E-mail: zhuzhh@pumch.cn
    LI Sijin3, E-mail: lisjnm123@163.com
    WANG Fan4, E-mail: wangfan@bjmu.edu.cn
    1. Department of Nuclear Medicine, Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
    2. State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
    3. Department of Nuclear Medicine, First Hospital of Shanxi Medical University, Taiyuan 030001, China
    4. Medical Isotopes Research Center, Peking University, Beijing 100191, China

  • Received Date: February 26, 2022
  • Accepted Date: March 14, 2022
  • Issue Publish Date: March 29, 2022
    Graphical Abstract
    • Abstract
  • Integrin is a group of transmembrane glycoprotein that mediates cell-cell adhesion and signal transduction. It regulates cell adhesion, migration, proliferation, apoptosis and other functions. It is highly expressed on the surface of neovascular endothelial cells and a variety of malignant tumor cells. The peptides witharginine-glycine-aspartate (RGD) motif can specifically bind to multiplesubtypes of integrin including αVβ3. When labeled with radionuclides for single photon emission tomography (SPECT) or positron emission tomography (PET), the RGD-based peptides can non-invasively reveal the tumor characteristics, including invasion and metastasis, as well as evaluate angiogenesis in vivo. These methods have shown strong value in clinical application. Based on the home-and-abroad progress in relevant clinical research, this expert consensus aims to establish principles for clinical application of RGD-based peptides to integrin imaging.
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    • References (37)
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