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Volume 13 Issue 3
May  2022
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SUN Fengrun, LI Mohan, HE Yumiao, WANG Tao, MA Chao, HUANG Yuguang. Application of Extended-release Local Anesthetics Based on Composite Polymer Materials in an Animal Model of Chronic Pain[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(3): 433-439. DOI: 10.12290/xhyxzz.2022-0086
Citation: SUN Fengrun, LI Mohan, HE Yumiao, WANG Tao, MA Chao, HUANG Yuguang. Application of Extended-release Local Anesthetics Based on Composite Polymer Materials in an Animal Model of Chronic Pain[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(3): 433-439. DOI: 10.12290/xhyxzz.2022-0086
shu

Application of Extended-release Local Anesthetics Based on Composite Polymer Materials in an Animal Model of Chronic Pain

  • 1.

    Department of Human Anatomy, Histology and Embryology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing 100005, China

  • 3.

    Department of Anesthesiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

  • 3.

    Joint Laboratory of Anesthesia and Pain, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

Funds: 

National Natural Science Foundation of China 81771205

Postdoctoral Science Foundation of China 2020M680453

More Information
  • Corresponding author:

    MA Chao, E-mail: machao@ibms.cams.cn

    HUANG Yuguang, E-mail: garypumch@163.com

  • Received Date: February 24, 2022
  • Accepted Date: April 10, 2022
  • Issue Publish Date: May 29, 2022
    Graphical Abstract
    • Abstract
  •   Objective  To evaluate the release characteristics and analgesic effect of extended-release composite polymers of local anesthetics.
      Methods  Polymer extended-release film containing bupivacaine hydrochloride was prepared via electrospinning (nanomembrane, group M), and was furthermore loaded intoPLGA-PEG-PLGA thermo-sensitive gel forming composite extended-release carrier (group G). The in vitro release profile, analgesic effect and safety in vivo were evaluated.
      Results  In vitro, the cumulative release of bupivacaine hydrochloride reached more than 5 d in the group M and 10 d in the group G. In vivo, the analgesic effect in the model of chronic compression injury of sciatic nerve lasted for 14 d in the group M and group G. There was no significant difference between the two groups (P > 0.05). The peak plasma concentration of bupivacaine hydrochloride in the group M was (0.294±0.029)μg/L one day after drug administration, while (0.192±0.064)μg/L in the group G three days after drug administration, which were far below the toxic plasma level of bupivacaine chloride. Meanwhile, there were no significant pathological changes in the heart, liver, spleen, lung and kidney of the two groups.
      Conclusions  In this study, the composite extended-release drug delivery prepared by bupivacaine hydrochloride electrospinning film as the basis and PLGA-PEG-PLGA thermo-sensitive gel can further prolong the release time of bupivacaine chloride and exhibit long-term analgesic effect without toxicity.
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