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Volume 13 Issue 3
May  2022
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LI Mohan, SUN Fengrun, WANG Tao, HE Yumiao, MA Chao, HUANG Yuguang. Transdermal Technology of Local Anesthetics in Plastic and Cosmetic Surgery[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(3): 358-362. DOI: 10.12290/xhyxzz.2022-0044
Citation: LI Mohan, SUN Fengrun, WANG Tao, HE Yumiao, MA Chao, HUANG Yuguang. Transdermal Technology of Local Anesthetics in Plastic and Cosmetic Surgery[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(3): 358-362. DOI: 10.12290/xhyxzz.2022-0044
shu

Transdermal Technology of Local Anesthetics in Plastic and Cosmetic Surgery

  • 1.

    Department of Anesthesiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

  • 2.

    Joint Laboratory of Anesthesia and Pain, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

  • 3.

    Department of Human Anatomy, Histology and Embryology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing 100005, China

Funds: 

National Natural Science Foundation of China 81771205

More Information
  • Corresponding author:

    MA Chao, E-mail: machao@ibms.cams.cn

  • Received Date: February 01, 2022
  • Accepted Date: April 05, 2022
  • Available Online: April 24, 2022
  • Issue Publish Date: May 29, 2022
    Graphical Abstract
    • Abstract
  • Intraoperative anesthesia can be divided into general anesthesia and local anesthesia according to the distribution of anesthetic drugs, and local anesthesia has broad applications in plastic surgery. The short acting time and poor lipid solubility of local anesthetics on conventional dosage limit their application in transdermal delivery. In recent years, there has been rapid developments in the topical analgesic transdermal delivery system, through which a drug penetrates the cuticle of the skin and enters the dermis to block the introduction of nerve terminal pain, so as to achieve the analgesic effect. In addition, transdermal administration can significantly increase safety and patient comfort compared to injectable administration. In this review, the commonly used methods of promoting transdermal absorption and topical analgesics on the market were overviewed, and the application and future direction of anesthetics in plastic and cosmetic surgery were prospected based on the research progress.
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    • References (33)
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