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Volume 13 Issue 6
Nov.  2022
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CAO Jun, QIN Jinmei, XUE Weizhen. Recent Advances in the Pathogenesis of Coronary Microvascular Disease: The role of Inflammatory Reactions[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(6): 1057-1063. DOI: 10.12290/xhyxzz.2021-0782
Citation: CAO Jun, QIN Jinmei, XUE Weizhen. Recent Advances in the Pathogenesis of Coronary Microvascular Disease: The role of Inflammatory Reactions[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(6): 1057-1063. DOI: 10.12290/xhyxzz.2021-0782
shu

Recent Advances in the Pathogenesis of Coronary Microvascular Disease: The role of Inflammatory Reactions

  • 1.

    Shanxi Medical University, Taiyuan 030000, China

  • 2.

    Department of Cardiology, Taiyuan Central Hospital of Shanxi Medical University, Taiyuan 030001, China

Funds: 

Scientific Research Project of Health Commission of Shanxi Province 2017140

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  • Corresponding author:

    XUE Weizhen, E-mail: tyby6387@163.com

  • Received Date: December 09, 2021
  • Accepted Date: January 10, 2022
  • Available Online: November 06, 2022
  • Issue Publish Date: November 29, 2022
    Graphical Abstract
    • Abstract
  • Coronary microvascular disease(CMVD)is the main cause of myocardial ischemia in patients with non-obstructive coronary artery disease. However, there is still a lack of comprehensive understanding of its pathophysiological mechanism due to the hidden pathogenesis and complex etiologies, which greatly restricts its clinical diagnosis and treatment. The injury of coronary artery microvascular endothelial cells is central to the induction of CMVD, and various inflammatory factors can participate in the pathogenesis of CMVD through the endothelial cell injury pathway. This article mainly reviews the possible mechanisms of inflammatory response in CMVD, in the hope of providing reference for the diagnosis, treatment and prevention of CMVD.
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