Email Alert RSS
Volume 12 Issue 4
Jul.  2021
Turn off MathJax
Article Contents
Abstract
References
Related Articles
LIU Zhijuan, ZOU Yutong, MA Chaochao, LIU Xiaoxing, ZEJI Puchi, TIAN Liping, LI Honglei, HOU Li'an, WANG Danchen, PANG Jinrong, YANG Hongyan, QIU Ling. Analysis on Serological Parameters Related to Erythrocyte Metabolism of People in Areas at Different High-altitude in Tibet[J]. Medical Journal of Peking Union Medical College Hospital, 2021, 12(4): 560-567. DOI: 10.12290/xhyxzz.2021-0321
Citation: LIU Zhijuan, ZOU Yutong, MA Chaochao, LIU Xiaoxing, ZEJI Puchi, TIAN Liping, LI Honglei, HOU Li'an, WANG Danchen, PANG Jinrong, YANG Hongyan, QIU Ling. Analysis on Serological Parameters Related to Erythrocyte Metabolism of People in Areas at Different High-altitude in Tibet[J]. Medical Journal of Peking Union Medical College Hospital, 2021, 12(4): 560-567. DOI: 10.12290/xhyxzz.2021-0321
shu

Analysis on Serological Parameters Related to Erythrocyte Metabolism of People in Areas at Different High-altitude in Tibet

  • 1.

    Department of Clinical Laboratory, People's Hospital of Tibet Autonomous Region, Lhasa 85000, China

  • 2.

    Department of Clinical Laboratory, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medcial College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

  • 3.

    Department of Clinical Laboratory, Ngari Prefecture People's Hospital, Tibet, Ngari 85900, China

  • 4.

    Department of Clinical Laboratory, Sangzizhu District People's Hospital, Tibet, Xigaze 847000, China

  • 5.

    Department of Clinical Laboratory, Nyingchi's Maternal and Child Health Hospital, Tibet, Nyingchi 860000, China

Funds: 

Science and Technology Program of Tibet Autonomous Region 2016XZ01G20

Talent Resources Development Special Project of Tibet Autonomous Region 2016

the Natural Science Foundation of Tibet Autonomous Region 2015ZR-14-51

More Information
  • Corresponding author:

    QIU Ling  Tel: 86-10-69159712, E-mail: lingqiubj@163.com

  • Received Date: April 08, 2021
  • Accepted Date: May 20, 2021
  • Issue Publish Date: July 29, 2021
    Graphical Abstract
    • Abstract
  •   Objective  To explore the characteristics of serological parameters related to erythrocyte metabolism in Tibetans living at different altitudes in Tibet, and to establish the reference intervals of each parameter.
      Methods  The cluster-sampling method was used to randomly select residents from Ngari (altitude Ⅰ, 4298-4352 m), Lhasa and Xigaze (altitudeⅡ, 3670-3835 m), and Nyingchi (altitude Ⅲ, about 2900 m) in Tibet from September 2016 to August 2018. Blood samples were collected for the determination of the whole blood-cell count, serum iron (SI), unsaturated ironbinding capacity (UIBC), transferrin (TRF), ferritin (FER), folic acid (FA), and vitamin B12(Vit B12). Transferrin saturation (TSAT) was calculated. Multiple linear regression and variance component analysis were used to compare the differences in gender, age, and altitude for various laboratory parameters among Tibetan population. The reference intervals of the laboratory parameters were established by the transformed parameter method.
      Results  A total of 1128 Tibetans were included in this study, of which 937 subjects were used to establish the reference intervals. The levels of SI, TSAT and FER in males were significantly higher than those in females (all P < 0.001). TRF, FA and UIBC in males were significantly lower than those in females (all P < 0.001). TRF and UIBC decreased with age; FER increased with age; the highest Vit B12 was in the 30-39 age group; SI, TSAT, FER and Vit B12 increased with altitude (all P < 0.001); the highest TRF and UIBC were at the altitude Ⅱ and the lowest at the altitude Ⅲ. The reference intervals of each index is shown as follows: 4.5-35.6 μmol/L in females and 10.6-41.1 μmol/L in males for SI; 19.9-79.5 μmol/L in females and 16.4-63.9 μmol/L in males for UIBC; 1.90-3.64 g/L for TRF; 5.3%-58.2% in females and 16.4%-68.8% in males for TSAT; 4.81-953.15 μg/L in females at the altitude Ⅰ and Ⅱ, 4.85-459.53 μg/L in females at the altitude Ⅲ, 50.55-1677.28 μg/L in males at altitude Ⅰ and Ⅱ, and 48.68-1239.30 μg/L in males at altitude Ⅲ for FER; 1.96-9.76 μg/L for FA; 176.3-1162.3 ng/L for Vit B12.
      Conclusions  There are gender/age/altitude differences in serological parameters related to erythrocyte metabolism among residents in areas at the high altitude. The distribution is also different from that in plain areas. Therefore, it is necessary to establish specific reference intervals for the population in Tibet.
    • FullText(HTML)
    • References (20)
  • [1]
    国胜, 陈家言, 胡永红, 等. 西藏自治区居民血糖和血脂状况调查[J]. 中国慢性病预防与控制, 2003, 25: 42-45. https://www.cnki.com.cn/Article/CJFDTOTAL-ZMXB201701011.htm
    [2]
    杨敏, 裴晓方. 高海拔民族地区健康人群血流变指标基本情况探索[J]. 现代预防医学, 2019, 9: 1939-1643. https://www.cnki.com.cn/Article/CJFDTOTAL-XDYF201909026.htm

    Yang M, Pei XF. Blood rheology characteristics of people in high altitude ethnic areas[J]. Xiandai Yufang Yixue, 2019, 9: 1939-1643. https://www.cnki.com.cn/Article/CJFDTOTAL-XDYF201909026.htm
    [3]
    李雪, 李文斌, 封士兰, 等. 血红蛋白在高原低氧适应中的机制研究进展[J]. 浙江大学学报(医学版), 2019, 48: 674-681. https://www.cnki.com.cn/Article/CJFDTOTAL-ZJYB201906021.htm

    Li X, Li WB, Feng SL, et al. Research progress on mechanism in adaptaion of hemoglobin to plateau hypoxia[J]. Zhejiang Daxue Xuebao(Yixueban), 2019, 48: 674-681. https://www.cnki.com.cn/Article/CJFDTOTAL-ZJYB201906021.htm
    [4]
    白玛康卓, 巴桑次仁, 次仁央宗, 等. 不同海拔地区世居藏族人群高原红细胞增多症患病率的流行病学调查[J]. 第三军医大学学报, 2016, 38: 220-225. https://www.cnki.com.cn/Article/CJFDTOTAL-DSDX201603002.htm

    Baima KI, Basang CR, Ciren YZ, et al. Epidemiological investigation of high altitude polycythemia in native Tibetans dwelling in different altitude area[J]. Di-san Junyi Daxue Xuebao, 2016, 38: 220-225. https://www.cnki.com.cn/Article/CJFDTOTAL-DSDX201603002.htm
    [5]
    刘丽军, 张玉涛, 张致英, 等. 高原红细胞增多症的研究进展[J]. 国外医学(医学地理分册), 2018, 39: 93-97. https://www.cnki.com.cn/Article/CJFDTOTAL-GONE201803028.htm
    [6]
    德吉, 祝青, 杜逸枚, 等. 西藏大学学生血色素水平及影响因素分析[J]. 西藏大学学报(自然科学版), 2010, 25: 21-26. https://www.cnki.com.cn/Article/CJFDTOTAL-XZZK201001008.htm
    [7]
    孙舒瑶, 王溯源, 孙曾梅, 等. 西藏高原地区铁过载患者铁调素的水平变化[J]. 中国实验血液学杂志, 2020, 28: 1406-1409. https://www.cnki.com.cn/Article/CJFDTOTAL-XYSY202004060.htm

    Sun SY, Wang SY, Sun ZM, et al. Change of hepcidin in patients with iron overload at the tibet plateau[J]. Zhongguo Shiyan Xueyexue Zazhi, 2020, 28: 1406-1409. https://www.cnki.com.cn/Article/CJFDTOTAL-XYSY202004060.htm
    [8]
    中华人民共和国卫生部. WS/T405—2012. 血细胞分析参考区间[S/OL ]. (2012-12-25). https://www.antpedia.com/standard/6610870.html.
    [9]
    World Health Organization. Haemoglobin concentrations for the diagnosis of anaemia and assessment of severity[S/OL ]. (2011). https://apps.who.int/iris/handle/10665/85839.
    [10]
    Zou Y, Li H, Pang J, Liu X, et al. An evaluation of urine and serum iodine status in the population of Tibet, China: No longer an iodine-deficient region[J]. Nutrition, 2020, 82: 111033. http://www.sciencedirect.com/science/article/pii/S0899900720303166
    [11]
    Yamamoto Y, Hosogaya S, Osawa S, et al. Nationwide multicenter study aimed at the establishment of common reference intervals for standardized clinical laboratory tests in Japan[J]. Clin Chem Lab Med, 2013, 51: 1663-1672. http://europepmc.org/abstract/med/23612542
    [12]
    谢慎威, 陈波, 刘秉林, 等. 不同海拔高原习服汉族与世居藏族的血常规比较研究[J]. 西南国防医药, 2019, 29: 781-783. DOI: 10.3969/j.issn.1004-0188.2019.07.021

    Xie SW, Chen B, Liu BL, et al. Comparison of the routine blood indexes between acclimatized Han population and native Tibetan at different high altitudes[J]. Xinan Guofang Yiyao, 2019, 29: 781-783. DOI: 10.3969/j.issn.1004-0188.2019.07.021
    [13]
    索朗片多, 孙舒瑶, 李明霞, 等. 高原健康成年男性铁代谢的影响因素分析[J]. 四川大学学报(医学版), 2018, 49, 137-139. https://www.cnki.com.cn/Article/CJFDTOTAL-HXYK201806029.htm
    [14]
    Ferrari AD, Miranda JJ, Gilman RH, et al. Prevalence, Clinical Profile, Iron Status, and Subject-Specific Traits for Excessive Erythrocytosis in Andean Adults Living Permanen-tly at 3, 825 Meters Above Sea Level[J]. Chest, 2014, 146: 1327-1336. DOI: 10.1378/chest.14-0298
    [15]
    中华医学会血液学分会. 铁过载诊断与治疗的中国专家共识[J]. 中华血液学杂志, 2011, 32: 572-574. DOI: 10.3760/cma.j.issn.0253-2727.2011.08.021
    [16]
    魏贤. 血清叶酸、维生素B12、铁蛋白联合检测对贫血早期的诊断价值[J]. 临床检验杂志(电子版), 2017, 6: 685-686. https://www.cnki.com.cn/Article/CJFDTOTAL-LNJI201704031.htm
    [17]
    邓燕, 秦雪, 黄珊, 等. 广西防城港地区汉族健康成年男性血清叶酸和维生素B12正常参考值的建立[J]. 中国临床新医学, 2011, 4: 413-416. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYLN201105011.htm

    Deng Y, Qin X, Huang S, et al. Reference values for serum levels of B12 and folate in Han ehinc males from the Fangchenggang area[J]. Zhongguo Linchuang Xinyixue, 2011, 4: 413-416. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYLN201105011.htm
    [18]
    高利伟, 徐增让, 成升魁, 等. 西藏农村居民食物消费结构及膳食营养特征分析[J]. 资源科学, 2017, 39: 168-174. https://www.cnki.com.cn/Article/CJFDTOTAL-ZRZY201701017.htm
    [19]
    中华人民共和国国家卫生健康委员会. WS/T404.6-2015. 临床常用生化检验项目参考区间第6部分: 血清总钙、无机磷、镁、铁[S/OL ]. (2015-04-29). http://www.nhc.gov.cn/wjw/s9492/ 201504/fc914ad 5981a49a88213940422ad24e1.shtml.
    [20]
    中华人民共和国国家卫生健康委员会. WS/T404.9-2018. 临床常用生化检验项目参考区间第9部分: 血清C-反应蛋白、前白蛋白、转铁蛋白、β-微球蛋白[S/OL ]. (2018-12-12). http://www.nhc.gov.cn/wjw/s9492/201812/3728fb3be3fa40ba9cd82b2f4dc597f9.shtml.
    • Related Articles

  • Related Articles

    [1]CHEN Weiyun, DAI Yi, QIAN Min, LIANG Jinqian. Perioperative Management of SEPN1-Related Myopathy Accompanying Scoliosis: A Case Report[J]. Medical Journal of Peking Union Medical College Hospital. DOI: 10.12290/xhyxzz.2024-0428
    [2]ZHANG Shan, LIU Jie. Interpretation of NCCN Clinical Practice Guidelines for Primary Cutaneous Lymphomas (Version 1.2024) Based on the Current Diagnosis and Treatment Status of China[J]. Medical Journal of Peking Union Medical College Hospital, 2024, 15(5): 1029-1037. DOI: 10.12290/xhyxzz.2024-0605
    [3]ZHANG Ning, YANG Chenhao, ZHOU Liangrui, SUN Xiaohong, LIU Xiaohong, KANG Lin, LI Ji, LI Hailong. Cronkhite-Canada Syndrome Combined with Asymptomatic Novel Coronavirus Infection: A Case Report[J]. Medical Journal of Peking Union Medical College Hospital, 2024, 15(2): 406-412. DOI: 10.12290/xhyxzz.2023-0476
    [4]SHI Weihong, CHEN Lixia, YUAN Wangshu, ZHANG Yuhang, ZHANG Houqiang, ZHANG Huiling, YANG Yuying, LU Jiandong. Analysis of Pelvic Obliquity in Standing Position and during Walking in Patients with Different Types of Juvenile Idiopathic Scoliosis[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(6): 1224-1230. DOI: 10.12290/xhyxzz.2023-0224
    [5]LIU Yuan, ZHAO Lin. Update and Interpretation of 2022 National Comprehensive Cancer Network Clinical Practice Guidelines for Gastric Cancer[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(6): 999-1004. DOI: 10.12290/xhyxzz.2022-0271
    [8]Ming-sheng MA, Xü-de ZHANG, Min WEI, Shi-min ZHAO, Zheng-qing QIU. Efficacy of Low Dose Corticosteroid Therapy in Duchenne Muscular Dystrophy[J]. Medical Journal of Peking Union Medical College Hospital, 2014, 5(4): 384-388. DOI: 10.3969/j.issn.1674-9081.2014.04.006
    [10]Shuai TANG, Jie YI, Yu-guang HUANG. Cardiovascular Responses of Intubation with Shikani Seeing Optical Stylet and Macintosh Laryngoscope[J]. Medical Journal of Peking Union Medical College Hospital, 2012, 3(3): 314-317. DOI: 10.3969/j.issn.1674-9081.2012.03.015

Catalog

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (598) PDF downloads (41) Cited by()
    Related
    Address：Room 302,Third Floor,Building 7, No. 1 Shuaifuyuan, Wangfujing, Dongcheng District, Beijing 100730, China
    Tel：010-69154261/4262
    E - mail：medj@pumch.cn mjpumch@126.com
    Copyright of website：Editorial Office of Medical Journal of Peking Union Medical College Hospital

      Supported by: Beijing Renhe Information Technology Co., Ltd.  Baidu Analytics

      /

      DownLoad:  Full-Size Img  PowerPoint
      Return
      Return
      x Close Forever Close