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Volume 13 Issue 1
Jan.  2022
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LU Fei, ZHANG Ning, KANG Lin, SUN Xiaohong, TIAN Ran, GUO Xiaoxiao, LIU Yongjian, ZHANG Wen, PENG Linyi, SU Tong, CAO Jian, WANG Yining, QIAN Min, CAO Yuze, YANG Lu, LIU Yuehua, ZHANG Lu, ZHAO Xiaoyi, LENG Ling. Decreased Muscle Strength, Type 2 Respiratory Failure, Heart Failure, Positive Anti-mitochondrial Antibodies—Rare Atypical Manifestations of Inflammatory Myopathy[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(1): 138-146. DOI: 10.12290/xhyxzz.2020-0109
Citation: LU Fei, ZHANG Ning, KANG Lin, SUN Xiaohong, TIAN Ran, GUO Xiaoxiao, LIU Yongjian, ZHANG Wen, PENG Linyi, SU Tong, CAO Jian, WANG Yining, QIAN Min, CAO Yuze, YANG Lu, LIU Yuehua, ZHANG Lu, ZHAO Xiaoyi, LENG Ling. Decreased Muscle Strength, Type 2 Respiratory Failure, Heart Failure, Positive Anti-mitochondrial Antibodies—Rare Atypical Manifestations of Inflammatory Myopathy[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(1): 138-146. DOI: 10.12290/xhyxzz.2020-0109
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Decreased Muscle Strength, Type 2 Respiratory Failure, Heart Failure, Positive Anti-mitochondrial Antibodies—Rare Atypical Manifestations of Inflammatory Myopathy

  • 1.

    Department of Geriatrics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

  • 2.

    Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

  • 3.

    Department of Pulmonary and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

  • 4.

    Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

  • 5.

    Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

  • 6.

    Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

  • 7.

    Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

  • 8.

    Department of Rehabilitation Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

  • 9.

    Stem Cell Biology Platform of Medical Science Research Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

Funds: 

National Key R & D Program of China 2018YFC2000300

National Key R & D Program of China 2018YFC2002100

National Key R & D Program of China 2018YFC2002104

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  • Corresponding author:

    ZHANG Ning, E-mail: 253571870@qq.com

  • Received Date: December 29, 2020
  • Accepted Date: February 17, 2021
  • Available Online: June 06, 2021
  • Issue Publish Date: January 29, 2022
    Graphical Abstract
    • Abstract
  • An elderly woman with a chronic course of disease presented with progressive weakness of lower limbs, heart failure, carbon dioxide retention, periorbital pigmentation, increased hair around the eyebrows, as well as multiple positive autoantibodies. After multidisciplinary team discussion, restrictive ventilatory dysfunction caused by significantly decreased diaphragm movement was taken as a breakthrough to sort out the etiology step by step. Based on clinical manifestations, serological and imaging features, as well as immunohistochemical staining of quadriceps femoris pathological complement, the final diagnosis of inflammatory myopathy associated with anti-mitochondrial antibodies was established. After correcting heart failure, intermittent non-invasive ventilation and rehabilitation training, clinical symptoms and functional status of the patient were significantly improved. The joint participation of the multidisciplinary team to identify the causes and solve problems in diagnosis and treatment decision-making reflects the great significance of multidisciplinary collaboration in rare diseases.
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    • References (14)
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