Email Alert RSS
Volume 11 Issue 2
Mar.  2020
Turn off MathJax
Article Contents
Abstract
References
Liang WANG, Zhu-jun SHEN. Intramyocardial Haemorrhage after Acute Myocardial Infarction[J]. Medical Journal of Peking Union Medical College Hospital, 2020, 11(2): 170-173. DOI: 10.3969/j.issn.1674-9081.20190263
Citation: Liang WANG, Zhu-jun SHEN. Intramyocardial Haemorrhage after Acute Myocardial Infarction[J]. Medical Journal of Peking Union Medical College Hospital, 2020, 11(2): 170-173. DOI: 10.3969/j.issn.1674-9081.20190263
shu

Intramyocardial Haemorrhage after Acute Myocardial Infarction

  • Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

More Information
  • Corresponding author:

    SHEN Zhu-jun Tel: 86-10-69155425, E-mail:zhujun66shen@126.com

  • Received Date: December 01, 2019
  • Issue Publish Date: March 29, 2020
    Graphical Abstract
    • Abstract
  • In patients with acute myocardial infarction, mechanical revascularization by percutaneous coronary intervention can effectively reduce mortality. However, a substantial proportion of patients with acute myocardial infarction develop chronic cardiac failure, despite restoration of epicardial vessel patency. It is found that the phenomenon of "no-reflow" caused by coronary microvascular obstruction and the subsequent myocardial hemorrhage are the important factors involved in this process. Understanding of the role of intramyocardial haemorrhage in the no-reflow phenomenon and myocardial injury is crucial to the development of new therapeutic strategies to treat acute myocardial infarction. In this article, we reviewed the latest development in pathophysiology, imaging, clinical significance, and therapeutic strategies of intramyocardial hemorrhage.
    • FullText(HTML)
    • References (37)
  • [1]
    Nabel EG, Braunwald E. A tale of coronary artery disease and myocardial infarction[J]. N Engl J Med, 2012, 366:54-63. DOI: 10.1056/NEJMra1112570
    [2]
    Levi F, Lucchini F, Negri E, et al. Trends in mortality from cardiovascular and cerebrovascular diseases in Europe and other areas of the world[J]. Heart, 2002, 88:119-124. DOI: 10.1136/heart.88.2.119
    [3]
    Wu X, Mintz GS, Xu K, et al. The relationship between attenuated plaque identified by intravascular ultrasound and no-reflow after stenting in acute myocardial infarction:the HORIZONS-AMI (Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction) trial[J]. JACC Cardiovasc Interv, 2011, 4:495-502. http://www.ncbi.nlm.nih.gov/pubmed/21596321
    [4]
    Robbers LF, Eerenberg ES, Teunissen PF, et al. Magnetic resonance imaging-defined areas of microvascular obstruction after acute myocardial infarction represent microvascular destruction and haemorrhage[J]. Eur Heart J, 2013, 34:2346-2353. DOI: 10.1093/eurheartj/eht100
    [5]
    Ganame J, Messalli G, Dymarkowski S, et al. Impact of myocardial haemorrhage on left ventricular function and remodelling in patients with reperfused acute myocardial infarction[J]. Eur Heart J, 2009, 30:1440-1449. DOI: 10.1093/eurheartj/ehp093
    [6]
    Jennings RB, Sommers HM, Smyth GA, et al. Myocardial necrosis induced by temporary occlusion of a coronary artery in the dog[J]. Arch Pathol, 1960, 70:68-78. http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=10.1177/000331979004100304
    [7]
    Kloner RA, Ganote CE, Jennings RB. The no-reflow phenomenon after temporary coronary occlusion in the dog[J]. J Clin Invest, 1974, 54:1496-1508. DOI: 10.1172/JCI107898
    [8]
    Mathey DG, Schofer J, Kuck KH, et al. Transmural, haemorrhagic myocardial infarction after intracoronary strepto-kinase. Clinical, angiographic, and necropsy findings[J]. Br Heart J, 1982, 48:546-551. DOI: 10.1136/hrt.48.6.546
    [9]
    Kali A, Tang RL, Kumar A, et al. Detection of acute reperfusion myocardial hemorrhage with cardiac MR imaging:T2 versus T2*[J]. Radiology, 2013, 269:387-395. DOI: 10.1148/radiol.13122397
    [10]
    McNamara JJ, Lacro RV, Yee M, et al. Hemorrhagic infarction and coronary reperfusion[J]. J Thorac Cardiovasc Surg, 1981, 81:498-501. DOI: 10.1016/S0022-5223(19)39478-4
    [11]
    Driesen RB, Zalewski J, Vanden Driessche N, et al. Histological correlate of a cardiac magnetic resonance imaged microvascular obstruction in a porcine model of ischemia-reperfusion[J]. Cardiovasc Pathol, 2012, 21:129-131. DOI: 10.1016/j.carpath.2011.07.008
    [12]
    Braunwald E, Kloner RA. Myocardial reperfusion:a double-edged sword?[J] J Clin Invest, 1985, 76:1713-1719. DOI: 10.1172/JCI112160
    [13]
    Zaman AK, French CJ, Spees JL, et al. Vascular rhexis in mice subjected to non-sustained myocardial ischemia and its therapeutic implications[J]. Exp Biol Med (Maywood), 2011, 236:598-603. DOI: 10.1258/ebm.2011.011026
    [14]
    Fishbein MC, Y-Rit J, Lando U, et al. The relationship of vascular injury and myocardial hemorrhage to necrosis after reperfusion[J]. Circulation, 1980, 62:1274-1279. DOI: 10.1161/01.CIR.62.6.1274
    [15]
    Reffelmann T, Kloner RA. Microvascular reperfusion injury:rapid expansion of anatomic no reflow during reperfusion in the rabbit[J]. Am J Physiol Heart Circ Physiol, 2002, 283:H1099- H1107. DOI: 10.1152/ajpheart.00270.2002
    [16]
    Marra MP, Cacciavillani L, Corbetti F, et al. The contribution of intramyocardial hemorrhage to the "no-reflow phenomenon":a study performed by cardiac magnetic resonance[J]. Echocardiography, 2010, 27:1120-1129. DOI: 10.1111/j.1540-8175.2010.01213.x
    [17]
    Bulluck H, Dharmakumar R, Arai AE, et al. Cardiovascular Magnetic Resonance in Acute ST-Segment-Elevation Myocardial Infarction:Recent Advances, Controversies, and Future Directions[J]. Circulation, 2018, 137:1949-1964. DOI: 10.1161/CIRCULATIONAHA.117.030693
    [18]
    周慷, 石海峰, 苏佰燕, 等.磁共振引导聚焦超声:现状与前景[J].协和医学杂志, 2020, 11:1-5. http://kns.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFD&filename=XHYX202001002
    [19]
    O'Regan DP, Ariff B, Neuwirth C, et al. Assessment of severe reperfusion injury with T2* cardiac MRI in patients with acute myocardial infarction[J]. Heart, 2010, 96:1885-1891. DOI: 10.1136/hrt.2010.200634
    [20]
    Hamirani YS, Wong A, Kramer CM, et al. Effect of microvascular obstruction and intramyocardial hemorrhage by CMR on LV remodeling and outcomes after myocardial infarction:a systematic review and meta-analysis[J]. JACC Cardiovasc Imaging, 2014, 7:940-952. DOI: 10.1016/j.jcmg.2014.06.012
    [21]
    Bulluck H, Rosmini S, Abdel-Gadir A, et al. Diagnostic performance of T1 and T2 mapping to detect intramyocardial hemorrhage in reperfused ST- segment elevation myocardial infarction (STEMI) patients[J]. J Magn Reson Imaging, 2017, 46:877-886. DOI: 10.1002/jmri.25638
    [22]
    Kali A, Cokic I, Tang R, et al. Persistent microvascular obstruction after myocardial infarction culminates in the confluence of ferric iron oxide crystals, proinflammatory burden, and adverse remodeling[J]. Circ Cardiovasc Imaging, 2016, 9.pii:e004996. http://www.ncbi.nlm.nih.gov/pubmed/27903536
    [23]
    Bulluck H, Rosmini S, Abdel-Gadir A, et al. Residual myocardial iron following intramyocardial hemorrhage during the convalescent phase of reperfused ST-segment-elevation myocardial infarction and adverse left ventricular remodeling[J]. Circ Cardiovasc Imaging, 2016, 9. pii:e004940. http://europepmc.org/articles/PMC5068185/
    [24]
    Carberry J, Carrick D, Haig C, et al. Persistent iron within the infarct core after ST-segment elevation myocardial infarction:implications for left ventricular remodeling and health outcomes[J]. JACC Cardiovasc Imaging, 2018, 11:1248-1256. DOI: 10.1016/j.jcmg.2017.08.027
    [25]
    Reinstadler SJ, Stiermaier T, Reindl M, et al. Intramyocardial haemorrhage and prognosis after ST-elevation myocardial infarction[J]. Eur Heart J Cardiovasc Imaging, 2019, 20:138-146. DOI: 10.1093/ehjci/jey101
    [26]
    Beek AM, Nijveldt R, van Rossum AC. Intramyocardial hemorrhage and microvascular obstruction after primary percutaneous coronary intervention[J]. Int J Cardiovasc Imaging, 2010, 26:49-55. DOI: 10.1007/s10554-009-9499-1
    [27]
    Amabile N, Jacquier A, Shuhab A, et al. Incidence, predictors, and prognostic value of intramyocardial hemorrhage lesions in ST elevation myocardial infarction[J]. Catheter Cardiovasc Interv, 2012, 79:1101-1108. DOI: 10.1002/ccd.23278
    [28]
    Stork A, Lund GK, Muellerleile K, et al. Characterization of the peri-infarction zone using T2-weighted MRI and delayed-enhancement MRI in patients with acute myocardial infarction[J]. Eur Radiol, 2006, 16:2350-2357. DOI: 10.1007/s00330-006-0232-3
    [29]
    Tartan Z, Ozer N, Uyarel H, et al. Metabolic syndrome is a predictor for an ECG sign of no-reflow after primary PCI in patients with acute ST-elevation myocardial infarction[J]. Nutr Metab Cardiovasc Dis, 2008, 18:441-447. DOI: 10.1016/j.numecd.2007.02.015
    [30]
    Amier RP, Tijssen RYG, Teunissen PFA, et al. Predictors of Intramyocardial Hemorrhage After Reperfused ST-Segment Elevation Myocardial Infarction[J]. J Am Heart Assoc, 2017, 6.pii:e005651. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5586425/
    [31]
    Maxwell L, Gavin JB. The role of post-ischaemic reperfusion in the development of microvascular incompetence and ultrastructural damage in the myocardium[J]. Basic Res Cardiol, 1991, 86:544-553. DOI: 10.1007/BF02190704
    [32]
    Kloner RA. Current state of clinical translation of cardioprotective agents for acute myocardial infarction[J]. Circ Res, 2013, 113:451-463. DOI: 10.1161/CIRCRESAHA.112.300627
    [33]
    Zhang J, Ding L, Zhao Y, et al. Collagen-targeting vascular endothelial growth factor improves cardiac performance after myocardial infarction[J]. Circulation, 2009, 119:1776-1784. DOI: 10.1161/CIRCULATIONAHA.108.800565
    [34]
    Huang RL, Teo Z, Chong HC, et al. ANGPTL4 modulates vascular junction integrity by integrin signaling and disruption of intercellular VE-cadherin and claudin-5 clusters[J]. Blood, 2011, 118:3990-4002. http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=4bcc02c9afc451f51e06008e02cfa0bc
    [35]
    Sandhu R, Teichert-Kuliszewska K, Nag S, et al. Reci-procal regulation of angiopoietin-1 and angiopoietin-2 following myocardial infarction in the rat[J]. Cardiovasc Res, 2004, 64:115-124. DOI: 10.1016/j.cardiores.2004.05.013
    [36]
    Copin JC, Merlani P, Sugawara T, et al. Delayed matrix metalloproteinase inhibition reduces intracerebral hemorrhage after embolic stroke in rats[J]. Exp Neurol, 2008, 213:196-201. DOI: 10.1016/j.expneurol.2008.05.022
    [37]
    Betgem RP, de Waard GA, Nijveldt R, et al. Intramy-ocardial haemorrhage after acute myocardial infarction[J]. Nat Rev Cardiol, 2015, 12:156-167. DOI: 10.1038/nrcardio.2014.188
    • Related Articles

  • Cited by

    Periodical cited type(4)

    1. 酉鹏华，梁健，韩稳琦. 心肌梗死患者PCI后发生心肌内出血的影响因素分析及其风险预测列线图模型构建与验证. 实用心脑肺血管病杂志. 2024(07): 10-15 .
    2. 向春林，李浩杰，黄璐，唐大中，夏黎明. 心脏磁共振成像在心肌梗死中的应用进展. 临床放射学杂志. 2022(04): 779-785 .
    3. 郭施勉，楚英杰. 脂联素通过Nrf2/HO-1通路对急性心肌梗死大鼠心功能和心肌细胞凋亡的作用机制. 中西医结合心脑血管病杂志. 2021(14): 2343-2347 .
    4. 罗一纯，简能日，李如利. 老年急性ST段抬高型心肌梗死患者经皮冠状动脉介入术后心肌内出血的危险因素分析. 中国医药. 2021(12): 1783-1786 .

    Other cited types(1)

Catalog

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (775) PDF downloads (110) Cited by(5)
    Related
    Links: National Health Commission of the People's Republic of China Chinese Academy of Medical Sciences(CAMS) AMLC Check CNKI Database CNKI Term Online Chinese General Practice
    Address：Room 302,Third Floor,Building 7, No. 1 Shuaifuyuan, Wangfujing, Dongcheng District, Beijing 100730, China
    Tel：010-69154261/4262
    E - mail：medj@pumch.cn mjpumch@126.com
    Copyright of website：Editorial Office of Medical Journal of Peking Union Medical College Hospital

    Supported by: Beijing Renhe Information Technology Co., Ltd.  Baidu Analytics

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return
    x Close Forever Close

    由中国科协、教育部、科技部、财政部、国家新闻出版署、中国科学院、中国工程院联合实施的“中国科技期刊卓越行动计划二期项目”结果于11月28日正式公布，《协和医学杂志》在激烈角逐中脱颖而出，入选“中文梯队期刊”。

    图片1.png

    图片2.png

    图片3.png

    图片4.png

    图片5.png




    经主动申报和严格评审，《协和医学杂志》于2024年12月20日正式被美国化学文摘社（Chemical Abstracts Service，CAS）数据库收录！

     image.png

    CAS数据库是美国化学会（American Chemical Society，ACS）的分支机构，创立于1907年，收录了全球数千种包括化学、生命科学等领域的期刊，为全球科研人员提供化学、生物医学等领域的专业信息服务。CAS也是全球化学、制药公司、大学、政府部门和专利机构公认的最大、最全面、最具权威的数据库。

    此次被CSA数据库收录，是继期刊被DOAJ、Scopus、WPRIM数据库收录后，进入的又一个重要国际数据库，标志着《协和医学杂志》的学术影响力得到更多国际数据库肯定，同时为国内外学者提供了更加广阔的交流平台！

     

     

     


    学术诚信是学术研究的基石，是学术界应共同遵守的基本原则。为充分利用新媒体传播渠道，搭建集学术诚信宣传、教育、监督于一体的平台，中国高校科技期刊研究会发起，联合“观见学术”公众号，建立“学术诚信与出版新媒体矩阵”。《协和医学杂志》新媒体平台成为首批“学术诚信与出版新媒体矩阵”成员单位。

      图片1.png

     


    2023年12月26日，《协和医学杂志》首次被评为《中文核心期刊要目总览》2023年版（即第10版）之综合性医药卫生(除一般理论，教育与普及)类核心期刊。