Abstract: Since its establishment in 1979, the multidisciplinary pituitary team (MPT) of Peking Union Medical College Hospital(PUMCH) has gone through more than 40 years. It is the first pituitary diagnosis and treatment center in China. Through the inheritance and improvement of generations in PUMCH, it has formed a mature operation mode with a complete process and distinct characteristics, which provides a systematic scheme for the diagnosis and treatment for refractory and complex pituitary tumors and plays an important role in clinical treatment, medical education, and scientific research related to pituitary diseases. This paper summarized the development history of MPT, the mode and flow path of diagnosis and treatment, typical cases, further thought and enlightenment, so as to provide experiences and references for the promotion of MPT in China.