Abstract: Since December 2019, China has been experiencing an outbreak of a new infectious disease caused by 2019 novel coronavirus (2019-nCoV). The clinical features include fever, coughing, shortness of breath, and inflammatory lung infiltration. China rapidly listed 2019-nCoV-related pneumonia as a statutory infectious disease. To standardize the diagnosis and treatment of this new infectious disease, an operational recommendation for the diagnosis and management of 2019-nCoV infection is developed by Peking Union Medical College Hospital.