Abstract: 2019 update of the EULAR recommendations for the management of systemic lupus erythematosus is the second edition that EULAR has developed for the general management of systemic lupus erythematosus (SLE) since 2007. The treatment strategy, validated goals of treatment, alternative regimens of glucocorticoids, "multi-targeted" therapy in lupus nephritis, and biological therapy for SLE were updated in the recommendations, which indicated the direction for the treatment of SLE. A detailed interpretation of the updated guidelines is provided in this article, aiming to provide references for the clinical diagnosis and treatment of SLE.