Abstract: Professor David Sackett was a physician scientist who was a critical thinker and advocated for modern medicine. He had mentored many pupils, disseminated the theory and concept of evidence-based medicine (EBM), and fully qualified the fame of Master defined by Chinese traditional culture. The primary contributions by Professor David Sackett include:(1)He pioneered to apply the methods of clinical epidemiology to clinical practice, and provided the basis and frame of EBM; (2)He established EBM centers at McMaster University and Oxford University, and cultivated a large number of talents; (3)By making EBM the reference standard for clinical research and practice, he changed modern medicine in a penetrating and powerful way. Professor David Sackett had a deep and strong relationship with Chinese scholars, and laid down the foundation for the development of clinical research and EBM in China.