微小RNA-21在肺动脉高压发病机制中的研究进展

MicroRNA-21 in the Pathogenesis of Pulmonary Hypertension

摘要: 微小RNA-21(microRNA-21, miRNA-21)是一种小的内源性非编码RNA, 可广泛表达于多种组织, 在多种疾病的发生和发展中发挥重要作用。近年来, miRNA-21在肺动脉高压中的作用受到广泛关注, 而其在各亚型中的角色不尽相同甚至相互矛盾。本文综述近年来miRNA-21在肺动脉高压中的研究进展, 从miRNA-21参与的病理生理过程、miRNA-21在各种类型肺动脉高压中的作用、当前研究的不足等方面加以综述, 以期明确miRNA-21在肺动脉高压发病机制中的作用, 为未来研究提供参考。

Abstract: MicroRNA-21(miRNA-21), a kind of small endogenous non-coding RNA, is widely expressed in various tissues and plays a pivotal role in the occurrence and development of many diseases. In recent years, the role of miRNA-21 in pulmonary hypertension(PH) has attracted extensive attention, and its function in subtypes of PH is not always the same or even contradictory. This review summarized recent advances of miRNA-21 in PH, encompassing pathophysiological processes mediated by miRNA-21, its roles in subtypes of PH, and insufficiency of current researches, in order to figure out the role of miRNA-21 in PH and provide a reference for future studies.