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胃底腺息肉与质子泵抑制剂及胃癌的相关性

黄诗琴,  徐杨

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文章导航 > 协和医学杂志  > 2021 >  12(2): 249-253
黄诗琴, 徐杨. 胃底腺息肉与质子泵抑制剂及胃癌的相关性[J]. 协和医学杂志, 2021, 12(2): 249-253. doi: 10.3969/j.issn.1674-9081.2020.00.016
引用本文: 黄诗琴, 徐杨. 胃底腺息肉与质子泵抑制剂及胃癌的相关性[J]. 协和医学杂志, 2021, 12(2): 249-253. doi: 10.3969/j.issn.1674-9081.2020.00.016
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HUANG Shi-qin, XU Yang. Correlation of Proton Pump Inhibitors and Gastric Carcinoma with Fundic Gland Polyps[J]. Medical Journal of Peking Union Medical College Hospital, 2021, 12(2): 249-253. doi: 10.3969/j.issn.1674-9081.2020.00.016
Citation: HUANG Shi-qin, XU Yang. Correlation of Proton Pump Inhibitors and Gastric Carcinoma with Fundic Gland Polyps[J]. Medical Journal of Peking Union Medical College Hospital, 2021, 12(2): 249-253. doi: 10.3969/j.issn.1674-9081.2020.00.016
shu

胃底腺息肉与质子泵抑制剂及胃癌的相关性

doi: 10.3969/j.issn.1674-9081.2020.00.016

  • 中南大学湘雅二医院消化内科，长沙 410011

详细信息
    通讯作者:

    徐 杨  电话：0731-85295149，E-mail: 13808432219xy@sina.com

  • 中图分类号: R735.2;R573

Correlation of Proton Pump Inhibitors and Gastric Carcinoma with Fundic Gland Polyps

  • Department of Gastroenterology, the Second Xiangya Hospital of Central South University, Changsha 410011, China

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    摘要
  • 摘要: 胃底腺息肉是胃底胃体黏膜形成的单发或多发性广基息肉样隆起，是目前国内外常见的息肉类型。其最初在家族性腺瘤性息肉病患者中被发现，越来越多的报道认为胃底腺息肉与质子泵抑制剂的长期使用相关。然而，国内对于长期接受质子泵抑制剂的患者中胃底腺息肉的发生率和发展情况调查研究较少，二者是否存在联系尚存争议，且胃底腺息肉是否与胃癌相关尚不明确。本文就胃底腺息肉与质子泵抑制剂及胃癌的相关性作一综述，旨在为胃底腺息肉的管理策略提供依据，以期促进质子泵抑制剂在临床的规范应用。
    Abstract: Fundic gland polyps are single or multiple wide-based polypoid protruding lesions formed by the mucous membrane of stomach fundus and body, which are common at home and abroad. They were initially described in patients with familial adenomatous polyposis and are now increasingly reported to be associated with long-term use of proton pump inhibitors. However, no definite conclusion has been drawn on the relationship between them. There are few studies on the incidence and development of fundic gland polyps in patients receiving long-term proton pump inhibitors in China. Whether there is a correlation between the two is still controversial, and whether fundic gland polyps are related to gastric carcinoma is not clear. This paper will review the relationship between fundic gland polyps and proton pump inhibitors and its correlation with gastric carcinoma, in order to provide evidence for the management strategy of fundic gland polyps and promote the standard application of proton pump inhibitors in clinical practice.
    作者贡献：黄诗琴负责查阅文献，撰写文章；徐杨审阅、修订文章。
    利益冲突：  无
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    • 参考文献(50)
  • [1] Goddard AF, Badreldin R, Pritchard DM, et al. The management of gastric polyps[J]. Gut, 2010, 59: 1270-1276. doi:  10.1136/gut.2009.182089
    [2] Carmack SW, Genta RM, Schuler CM, et al. The Current Spectrum of Gastric Polyps: A 1-Year National Study of over 120, 000 Patients[J]. Am J Gastroenterol, 2009, 104: 1524-1532. doi:  10.1038/ajg.2009.139
    [3] Sonnenberg A, Genta RM. Prevalence of benign gastric polyps in a large pathology database[J]. Dig Liver Dis, 2014, 47: 164-169. http://europepmc.org/abstract/med/25458775
    [4] Jalving M, Koornstra JJ, Wesseling J, et al. Increased risk of fundic gland polyps during long-term proton pump inhibitor therapy[J]. Aliment Pharmacol Ther, 2006, 24: 1341-1348. doi:  10.1111/j.1365-2036.2006.03127.x
    [5] Ally MR, Veerappan GR, Maydonovitch CL, et al. Chronic Proton Pump Inhibitor Therapy Associated with Increased Development of Fundic Gland Polyps[J]. Dig Dis Sci, 2009, 54: 2617-2622. doi:  10.1007/s10620-009-0993-z
    [6] Xie C, Lu NH. Clinical Management of Helicobacter pylori Infection in China[J]. Helicobacter, 2015, 20: 1-10. http://europepmc.org/abstract/med/25382801
    [7] Cao H, Wang B, Zhang Z, et al. Distribution trends of gastric polyps: An endoscopy database analysis of 24 121 northern Chinese patients[J]. J Gastroenterol Hepatol, 2012, 27: 1175-1180. doi:  10.1111/j.1440-1746.2012.07116.x
    [8] 何金龙, 陈磊, 代剑华, 等. 10137例胃息肉的临床及病理特征分析[J]. 第三军医大学学报, 2018, 40: 248-254. https://www.cnki.com.cn/Article/CJFDTOTAL-DSDX201803012.htm

    He JL, Chen L, Dai JH, et al. Clinical and pathological characteristics of gastric polyps: a report of 10 137 patients[J]. Di San Jun Yi Da Xue Xue Bao, 2018, 40: 248-254. https://www.cnki.com.cn/Article/CJFDTOTAL-DSDX201803012.htm
    [9] 林琳, 吴静, 刘揆亮, 等. 胃底腺息肉的临床和内镜特征分析[J]. 中国内镜杂志, 2017, 23: 26-29. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGNJ201702007.htm

    Lin L, Wu J, Liu KL, et al. Clinical and endoscopic characteristics of fundic gland polyps[J]. Zhongguo Nei Jing Za Zhi, 2017, 23: 26-29. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGNJ201702007.htm
    [10] Rubio CA, Nesi G. Fundic gland polyps[J]. Anticancer Res, 2011, 31: 1789-1793.
    [11] Bianchi LK, Burke CA, Bennett AE, et al. Fundic Gland Polyp Dysplasia Is Common in Familial Adenomatous Polyposis[J]. Clin Gastroenterol Hepatol, 2008, 6: 180-185. doi:  10.1016/j.cgh.2007.11.018
    [12] Aprile MR, Azzoni C, Gibril F, et al. Intramucosal cysts in the gastric body of patients with Zollinger-Ellison syndrome[J]. Hum Pathol, 2000, 31: 140-148. doi:  10.1016/S0046-8177(00)80213-0
    [13] Burt RW, Berenson MM, Lee RG, et al. Upper Gastrointestinal polyps in Gardner's syndrome[J]. Gastroenterology, 1984, 86: 295-301. doi:  10.1016/0016-5085(84)90414-1
    [14] Graham JR. Gastric polyposis: onset during long-term therapy with omeprazole[J]. Med J Aust, 1992, 157: 287-288. http://europepmc.org/abstract/MED/1406434
    [15] Choudhry U, Boyce HW, Coppola D. Proton Pump Inhibitor- Associated Gastric Polyps: A Retrospective Analysis of Their Frequency, and Endoscopic, Histologic, and Ultrastructural Characteristics[J]. Am J Clin Pathol, 1998, 110: 615-621. doi:  10.1093/ajcp/110.5.615
    [16] Zelter A, Fernandez JL, Bilder C, et al. Fundic gland polyps and association with proton pump inhibitor intake: a prospective study in 1, 780 endoscopies[J]. Dig Dis Sci, 2011, 56: 1743-1748. doi:  10.1007/s10620-010-1493-x
    [17] Yoshida N, Yamada S, Fukumoto K, et al. W1083 The Development of Fundic Gland Polyps Associated With Chronic Proton Pump Inhibitor Therapy Involves in Increased Expression of Aquaporin 4[J]. Gastroenterology, 2010, 138: S-648. http://www.sciencedirect.com/science/article/pii/S0016508510629824
    [18] Vieth M, Stolte M. Fundic Gland Polyps Are Not Induced by Proton Pump Inhibitor Therapy[J]. Am J Clin Pathol, 2001, 116: 716-720. doi:  10.1309/XFWR-LXA7-7TK1-N3Q8
    [19] Declich P, Tavani E, Ferrara A, et al. Sporadic fundic gland polyps: clinico-pathologic features and associated diseases[J]. Pol J Pathol, 2005, 56: 131-137. http://www.ncbi.nlm.nih.gov/pubmed/16334981
    [20] Cao H, Qu R, Zhang Z, et al. Sporadic fundic gland polyps are not associated with proton pump inhibitors therapy but negatively correlate with Helicobacter pylori infection in China[J]. Chin Med J (Engl), 2014, 127: 1239-1243. http://d.wanfangdata.com.cn/Periodical/zhcmj201407008
    [21] Huang CZ, Lai RX, Mai L, et al. Relative risk factors associated with the development of fundic gland polyps[J]. Eur J Gastroenterol Hepatol, 2014, 26: 1217-1221. doi:  10.1097/MEG.0000000000000199
    [22] 高鹤, 常丽丽, 高富贵, 等. 胃息肉患者质子泵抑制剂应用及胃液微环境变化分析[J]. 中华消化杂志, 2019, 39: 260-263.
    [23] Martin FC, Chenevix-Trench G, Yeomans ND. Systematic review with meta-analysis: fundic gland polyps and proton pump inhibitors[J]. Aliment Pharmacol Ther, 2016, 44: 915-925. doi:  10.1111/apt.13800
    [24] Tran-Duy A, Spaetgens B, Hoes AW, et al. Use of Proton Pump Inhibitors and Risks of Fundic Gland Polyps and Gastric Cancer: Systematic Review and Meta-analysis[J]. Clin Gastroenterol Hepatol, 2016, 14: 1706-1719. e5. doi:  10.1016/j.cgh.2016.05.018
    [25] Chen CL, Albers GC. Regression of Massive Polypoid Stalagmites: Gastric Fundic Gland Polyposis: Presidential Poster: 1166[J]. Am J Gastroenterol, 2015, 110: S510-511. doi:  10.14309/00000434-201510001-01166
    [26] Brockmeyer JR, Connolly EE, Wittchow RJ, et al. Resolu-tion of Fundic Gland Polyposis following Laparoscopic Magnetic Sphincter Augmentation and Subsequent Cessation of Proton Pump Inhibitors[J]. Case Rep Gastrointest Med, 2015, 2015: 576263. http://www.ncbi.nlm.nih.gov/pubmed/26600954
    [27] Kazantsev GB, Schwesinger WH, Heim-Hall J. Spontaneous resolution of multiple fundic gland polyps after cessation of treatment with lansoprazole and Nissen fundoplication: A case report[J]. Gastrointest Endosc, 2002, 55: 600-602. doi:  10.1067/mge.2002.122583
    [28] Varghese S, Le V, Ali T. Large Fundic Gland Polyps in the Stomach[J]. Gastroenterol Hepatol (N Y), 2016, 12: 153-154. http://pubmedcentralcanada.ca/pmcc/articles/PMC4872842/
    [29] Khalaf M, Brock AS, Castell D. Sporadic Fundic Gland Polyps and Gastric Acid Suppression Level[J]. Am J Med Sci, 2017, 354: 561-564. doi:  10.1016/j.amjms.2017.07.009
    [30] Cats A, Schenk BE, Bloemena E, et al. Parietal cell protrusions and fundic gland cysts during omeprazole maintenance treatment[J]. Hum Pathol, 2000, 31: 684-690. doi:  10.1053/hupa.2000.7637
    [31] Fukuda M, Ishigaki H, Sugimoto M, et al. Histological analysis of fundic gland polyps secondary to PPI therapy[J]. Histopathology, 2019, 75: 537-545. doi:  10.1111/his.13902
    [32] Hongo M, Fujimoto K, Group GPS. Incidence and risk factor of fundic gland polyp and hyperplastic polyp in long-term proton pump inhibitor therapy: a prospective study in Japan[J]. J Gastroenterol, 2010, 45: 618-624. doi:  10.1007/s00535-010-0207-7
    [33] Fossmark R, Jianu CS, Martinsen TC, et al. Serum gastrin and chromogranin A levels in patients with fundic gland polyps caused by long-term proton-pump inhibition[J]. Scand J Gastroenterol, 2008, 43: 20-24. doi:  10.1080/00365520701561959
    [34] Abraham SC, Park SJ, Mugartegui L, et al. Sporadic Fundic Gland Polyps with Epithelial Dysplasia: Evidence for Preferential Targeting for Mutations in the Adenomatous Polyposis Coli Gene[J]. Am J Pathol, 2002, 161: 1735-1742. doi:  10.1016/S0002-9440(10)64450-1
    [35] Kawase R, Nagata S, Onoyama M, et al. A case of gastric adenocarcinoma arising from a fundic gland polyp[J]. Clin J Gastroenterol, 2009, 2: 279-283. doi:  10.1007/s12328-009-0096-6
    [36] Togo K, Ueo T, Yonemasu H, et al. Two cases of adenocarcinoma occurring in sporadic fundic gland polyps observed by magnifying endoscopy with narrow band imaging[J]. World J Gastroenterol, 2016, 22: 9028-9034. doi:  10.3748/wjg.v22.i40.9028
    [37] Jeong YS, Kim SE, Kwon MJ, et al. Signet-ring cell carcinoma arising from a fundic gland polyp in the stomach[J]. World J Gastroenterol, 2014, 20: 18044-18047. doi:  10.3748/wjg.v20.i47.18044
    [38] Levy MD, Bhattacharya B. Sporadic Fundic Gland Polyps With Low-Grade Dysplasia: A Large Case Series Evaluating Pathologic and Immunohistochemical Findings and Clinical Behavior[J]. Am J Clin Pathol, 2015, 144: 592-600. doi:  10.1309/AJCPGK8QTYPUQJYL
    [39] Jalving M, Koornstra JJ, Gotz JM, et al. High-grade dysplasia in sporadic fundic gland polyps: a case report and review of the literature[J]. Eur J Gastroenterol Hepatol, 2003, 15: 1229-1233. doi:  10.1097/00042737-200311000-00013
    [40] Fukuda M, Ishigaki H, Ban H, et al. No transformation of a fundic gland polyp with dysplasia into invasive carcinoma after 14 years of follow-up in a proton pump inhibitor-treated patient: A case report[J]. Pathol Int, 2018, 68: 706-711. doi:  10.1111/pin.12739
    [41] 郭广英, 姜瑞勤, 邢建华, 等. 140例胃底腺息肉临床分析[J]. 内蒙古医学杂志, 2014, 46: 328-330. https://www.cnki.com.cn/Article/CJFDTOTAL-NMYZ201403029.htm
    [42] Lloyd IE, Kohlmann WK, Gligorich K, et al. A Clinicopathologic Evaluation of Incidental Fundic Gland Polyps With Dysplasia: Implications for Clinical Management[J]. Am J Gastroenterol, 2017, 112: 1094-1102. doi:  10.1038/ajg.2017.125
    [43] Straub SF, Drage MG, Gonzalez RS. Comparison of dysplastic fundic gland polyps in patients with and without familial adenomatous polyposis[J]. Histopathology, 2018, 72: 1172-1179. doi:  10.1111/his.13485
    [44] Yamashita K, Suzuki R, Kubo T, et al. Gastric Xanthomas and Fundic Gland Polyps as Endoscopic Risk Indicators of Gastric Cancer[J]. Gut Liver, 2019, 13: 409-414. doi:  10.5009/gnl17136
    [45] Genta RM, Schuler CM, Robiou CI, et al. No Association Between Gastric Fundic Gland Polyps and Gastrointestinal Neoplasia in a Study of Over 100, 000 Patients[J]. Clin Gastroenterol Hepatol, 2009, 7: 849-854. doi:  10.1016/j.cgh.2009.05.015
    [46] Yasuda T, Omatsu T, Yagi N. Fundic Gland Type Adenocarcinoma in Fundic Gland Polyps[J]. Intern Med, 2020, 59: 455-456. doi:  10.2169/internalmedicine.3768-19
    [47] Sharaf RN, Shergill AK, Odze RD, et al. Endoscopic mucosal tissue sampling[J]. Gastrointest Endosc, 2013, 78: 216-224. doi:  10.1016/j.gie.2013.04.167
    [48] Castro R, Pimentel-Nunes P, Dinis-Ribeiro M. Evaluation and management of gastric epithelial polyps[J]. Best Pract Res Clin Gastroenterol, 2017, 31: 381-387. doi:  10.1016/j.bpg.2017.06.001
    [49] Banks M, Graham D, Jansen M, et al. British Society of Gastroenterology guidelines on the diagnosis and management of patients at risk of gastric adenocarcinoma[J]. Gut, 2019, 68: 1545-1575. doi:  10.1136/gutjnl-2018-318126
    [50] Schmocker RK, Lidor AO. Management of Non-neoplastic Gastric Lesions[J]. Surg Clin North Am, 2017, 97: 387-403. doi:  10.1016/j.suc.2016.11.011
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出版历程
  • 收稿日期:  2019-11-18
  • 录用日期:  2020-08-20
  • 网络出版日期:  2020-12-01
  • 刊出日期:  2021-05-30

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