免疫检查点抑制剂相关甲状腺毒症

武凌鸽; 徐燕; 李乃适

doi:10.3969/j.issn.1674-9081.2020.00.004

免疫检查点抑制剂相关甲状腺毒症

doi: 10.3969/j.issn.1674-9081.2020.00.004

1.
中国医学科学院北京协和医学院北京协和医院内分泌科国家卫健委内分泌重点实验室, 北京 100730
2.
中国医学科学院北京协和医学院北京协和医院呼吸与危重症医学科, 北京 100730

基金项目:

国家“十三五”重大新药创制专项子课题“创新药物临床评价示范性平台建设” 2019ZX09734001-002

中国医学科学院医学与健康科技创新工程重大协同创新项目 2017-I2M-1-009

详细信息

通讯作者:
李乃适电话：010-69155073, E-mail：LNS@medmail.com.cn

中图分类号: R979.5; R581
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- 被引次数: 0
出版历程
- 收稿日期: 2020-04-13
- 录用日期: 2020-05-14
- 网络出版日期: 2020-08-14
- 刊出日期: 2021-01-30

Thyrotoxicosis Related to Immune Checkpoint Inhibitors

WU Ling-ge¹,
XU Yan²,
LI Nai-shi^{1
, ,}

1.
Department of Endocrinology, Key Laboratory of Endocrinology, National Health Commission of the People's Republic of China, Department of Respiratory and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
2.
Department of Respiratory and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

Funds:

"13th Five-Year"National Science and Technology Major Project for New Drugs 2019ZX09734001-002

CAMS Innovation Fund for Medical Sciences 2017-I2M-1-009

More Information

Corresponding author: LI Nai-shi Tel: 86-10-69155073, E-mail: LNS@medmail.com.cn

摘要

摘要: 免疫检查点抑制剂(immune checkpoint inhibitors, ICIs)是近年来恶性肿瘤治疗领域的一项重大突破。其通过针对T细胞的调节作用，增强抗肿瘤免疫反应，改善恶性肿瘤患者的预后，延长患者生存期，现已获批用于治疗多种肿瘤，但ICIs在应用过程中产生的甲状腺毒症是不容忽视的临床问题。本文对ICIs相关甲状腺毒症的发生机制、临床表现、处理对策等进行综述。
- 免疫检查点抑制剂 /
- 免疫相关不良反应 /
- 甲状腺毒症
Abstract: Immune checkpoint inhibitors (ICIs) have come out in recent years as a breakthrough of the treatments for malignant tumors by regulating T cells with the purpose of enhancing their anti-tumor response, which can improve prognosis and increase survival. However, thyrotoxicosis caused by ICIs has become a clinical problem that cannot be ignored. This review summarizes the pathogenic mechanisms, clinical manifesta-tions, and treatments of ICIs associated thyrotoxicosis.
- immune checkpoint inhibitors /
- immune-related adverse events /
- thyrotoxicosis
注释:

作者贡献：武凌鸽负责文献检索、数据分析及文章初稿撰写；李乃适、徐燕负责文章初稿修订；李乃适负责文章审校。

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参考文献(56)

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免疫检查点抑制剂相关甲状腺毒症

doi: 10.3969/j.issn.1674-9081.2020.00.004

通讯作者:
李乃适电话：010-69155073, E-mail：LNS@medmail.com.cn

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Thyrotoxicosis Related to Immune Checkpoint Inhibitors

Corresponding author: LI Nai-shi Tel: 86-10-69155073, E-mail: LNS@medmail.com.cn

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免疫检查点抑制剂相关甲状腺毒症

doi: 10.3969/j.issn.1674-9081.2020.00.004

通讯作者: 李乃适 电话：010-69155073, E-mail：LNS@medmail.com.cn

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出版历程

Thyrotoxicosis Related to Immune Checkpoint Inhibitors

Corresponding author: LI Nai-shi Tel: 86-10-69155073, E-mail: LNS@medmail.com.cn

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出版历程

目录

通讯作者:
李乃适电话：010-69155073, E-mail：LNS@medmail.com.cn