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摘要: 光声成像作为一种新兴的生物医学成像技术, 以光声效应为成像基础, 兼备光学高对比度、超声高穿透度的优点，同时具有光谱信息获取能力，可进行功能成像，具有良好的临床应用前景。乳腺肿瘤是目前光声成像技术临床应用最广泛的领域，本文综述光声成像技术特点及其在乳腺肿瘤的临床应用现状，并对未来应用前景进行展望。Abstract: Photoacoustic imaging(PAI) based on the photoacoustic effect is a new and promising biomedical imaging technology. It has the advantages of high optical contrast and deep ultrasonic penetration. Furthermore, it has the ability to acquire functional information based on optical imaging with multi-wavelength. The application of PAI in breast tumors has been widely explored. In this article, we reviewed the PAI systems and their clinical application to breast tumors over the past few years and looked into the prospect of the application of PAI in the future.
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Key words:
- photoacoustic imaging /
- breast tumor /
- diagnosis /
- biomedical application
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图 4 一例乳腺癌患者彩色多普勒超声及光声/超声双模态成像
A.彩色多普勒超声; B.光声/超声双模态：血氧饱和度; C.光声/超声双模态：波长750 nm; D.光声/超声双模态：波长830 nm
表 1 乳腺肿瘤光声成像设备及其参数简介
研发机构/团队 设备名称 分辨率 最大成像深度 扫描时间 参考文献 荷兰特温特大学 TPAM 3.0 mm 60 mm 10 min [35] Seno Medical Imagio 0.5 mm 30 mm - [42] Kruger团队 PAM 0.42 mm 40 mm 12 s~3.2 min [49] 京都大学/佳能联合研究中心 PAM-03 0.57 mm 30 mm 2~4 min [50] iThera Medical MSOT 250 μm 30 mm - [58] 佛罗里达大学 FPAT 0.5 mm 56 mm - [62] 汪立宏团队 SBH-PACT 255 μm 40 mm 15 s [63] 北京协和医院超声医学科/迈瑞团队 手持式光声/超声设备 0.1~1 mm 30 mm 5~10 min 待发表 TPAM：Twente光声乳腺镜; Imagio：手持式光声/超声多模态成像系统; PAM：光声乳腺成像系统; PAM-03：第三代光声乳腺成像系统; MSOT：多光谱光声层析成像系统; FPAT：功能性光声层析成像系统; SBH-PACT：单次屏气光声计算层析成像系统; -:未报道 
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