Abstract: Magnetic resonance-guided focused ultrasound is an advanced non-invasive therapeutic technique, which has great potential in targeted thermal ablation and blood-brain barrier opening treatment of central nervous system diseases. It has been used in the research and treatment of essential tremor, Parkinson's disease, intracranial tumors, Alzheimer's disease, obsessive-compulsive disorder, neuropathic pain, and other diseases now. Magnetic resonance-guided focused ultrasound therapy may be a potential alternative therapy for many diseases due to its advantages such as precision, non-ionizing radiation, and real-time monitoring of target temperature. In this article, we reviewed the progress of magnetic resonance-guided focused ultrasound therapy in clinical applications and scientific researches.