多发性骨髓瘤的影像学评估

赵多多; 庄俊玲

doi:10.3969/j.issn.1674-9081.20190213

多发性骨髓瘤的影像学评估

doi: 10.3969/j.issn.1674-9081.20190213

赵多多,
庄俊玲^,

中国医学科学院北京协和医学院北京协和医院血液内科, 北京 100730

基金项目:

北京市自然科学基金 7192175

详细信息

通讯作者:
庄俊玲电话:010-69155027,E-mail:zhuangjunling@pumch.cn

中图分类号: R445.1;R551.3
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出版历程
- 收稿日期: 2019-10-06
- 刊出日期: 2020-05-30

Imaging Techniques in the Assessment of Multiple Myeloma

Duo-duo ZHAO,
Jun-ling ZHUANG^,

Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

More Information

Corresponding author: ZHUANG Jun-ling Tel:86-10-69155027,E-mail:zhuangjunling@pumch.cn

摘要

摘要: 多发性骨髓瘤具有独特的骨病表现,由于破骨细胞激活和成骨细胞功能抑制导致溶骨性破坏和严重骨质疏松。骨病严重程度对患者生活质量和生存均有负面影响。普通X线检出骨病的灵敏度很低,CT的灵敏度虽明显提高,但难以检出骨外病变。功能性影像方法(主要包括磁共振弥散加权成像和正电子发射断层显像/计算机体层成像)不仅能发现早期溶骨病灶,且在评估全身肿瘤负荷和缓解后微小残留病变方面更有优势。本文将对这些方面的进展进行综述。
- 多发性骨髓瘤 /
- 影像 /
- 骨病 /
- 微小残留病变 /
- 肿瘤负荷
Abstract: Multiple myeloma has unique manifestations of bone disease, mainly presenting as osteolytic lesions and diffuse osteoporosis as a result of over-activation of osteoclasts and suppression of osteoblasts. The severity of myeloma bone disease is negatively correlated with quality of life and survival. Plain X ray has low sensitivity to contour destructive bone lesions. Whole body low dose CT does not differentiate active foci from tranquil ones. Functional imaging including diffuse weighted imaging-magnetic resonance imaging (DWI-MRI) and positron emission tomography/computed tomography (PET/CT) are more sensitive in evaluation of comprehensive tumor load and detection of early disease. Moreover, minimal residue disease detected by DWI-MRI or PET/CT is a complement of flow cytometry and predicts progressive disease in patients achieving complete response. In this article, we summarized the role of imaging methods in evaluating myeloma bone disease and tumor load.
- multiple myeloma /
- imaging /
- bone disease /
- minimal residual disease /
- tumor load
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参考文献(24)

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多发性骨髓瘤的影像学评估

doi: 10.3969/j.issn.1674-9081.20190213

通讯作者:
庄俊玲电话:010-69155027,E-mail:zhuangjunling@pumch.cn

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Imaging Techniques in the Assessment of Multiple Myeloma

Corresponding author: ZHUANG Jun-ling Tel:86-10-69155027,E-mail:zhuangjunling@pumch.cn

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多发性骨髓瘤的影像学评估

doi: 10.3969/j.issn.1674-9081.20190213

通讯作者: 庄俊玲 电话:010-69155027,E-mail:zhuangjunling@pumch.cn

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出版历程

Imaging Techniques in the Assessment of Multiple Myeloma

Corresponding author: ZHUANG Jun-ling Tel:86-10-69155027,E-mail:zhuangjunling@pumch.cn

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出版历程

目录

通讯作者:
庄俊玲电话:010-69155027,E-mail:zhuangjunling@pumch.cn