Abstract: Magnetic resonance-guided focused ultrasound(MRgFUS) is a new technique of tumor thermal ablation that has appeared in recent years. It is a kind of treatment that can use the ultrasonic beam to focus on the target after passing through soft tissue so that the target area produces a high temperature instantaneously and makes coagulating necrosis in the tissue. The range and temperature change of the treatment area are monitored by MR synchronously. This technology is completely non-invasive and non-ionizing with no anesthesia, no hospitalization, but only a small amount of sedatives required. At present, this treatment method is widely used in uterine fibroids/adenomyosis, bone tumors, prostate cancer, functional neural diseases, breast cancer, and so on. MRgFUS has become a hot topic of research and clinical application.