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贝利木单克隆抗体:治疗系统性红斑狼疮的新型靶向药物

贺成美,  张奉春

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文章导航 > 协和医学杂志  > 2020 >  11(2): 130-134
贺成美, 张奉春. 贝利木单克隆抗体:治疗系统性红斑狼疮的新型靶向药物[J]. 协和医学杂志, 2020, 11(2): 130-134. doi: 10.3969/j.issn.1674-9081.20190114
引用本文: 贺成美, 张奉春. 贝利木单克隆抗体:治疗系统性红斑狼疮的新型靶向药物[J]. 协和医学杂志, 2020, 11(2): 130-134. doi: 10.3969/j.issn.1674-9081.20190114
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Cheng-mei HE, Feng-chun ZHANG. Belimumab:A New Targeted Drug for Systemic Lupus Erythematosus[J]. Medical Journal of Peking Union Medical College Hospital, 2020, 11(2): 130-134. doi: 10.3969/j.issn.1674-9081.20190114
Citation: Cheng-mei HE, Feng-chun ZHANG. Belimumab:A New Targeted Drug for Systemic Lupus Erythematosus[J]. Medical Journal of Peking Union Medical College Hospital, 2020, 11(2): 130-134. doi: 10.3969/j.issn.1674-9081.20190114
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贝利木单克隆抗体:治疗系统性红斑狼疮的新型靶向药物

doi: 10.3969/j.issn.1674-9081.20190114

  • 中国医学科学院 北京协和医学院 北京协和医院风湿免疫科, 北京 100730

详细信息
    通讯作者:

    张奉春 电话:010-69155007, E-mail:zhangfccra@aliyun.com

  • 中图分类号: R593.24;R453

Belimumab:A New Targeted Drug for Systemic Lupus Erythematosus

  • Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

More Information

    摘要
  • 摘要: 系统性红斑狼疮(systemic lupus erythematosus, SLE)是一种复杂的自身免疫性疾病, B细胞异常活化在发病中起重要作用。贝利木单克隆抗体是一种人源化单克隆抗体, 能通过结合肿瘤坏死因子家族B细胞活化因子(B-cell-activating factor of the tumor necrosis factor family, BAFF), 减少活化B细胞的数量。2011年美国食品药品监督管理局批准贝利木单克隆抗体上市, 为SLE患者提供了新的用药选择。本文主要介绍贝利木单克隆抗体治疗机制及相关临床研究, 并对其未来进行展望。
    Abstract: Systemic lupus erythematosus(SLE) is a complicated autoimmune disease characterized by aberrant B cell activation. Belimumab is a human monoclonal antibody, which can reduce active B cells through binding to the B-cell-activating factor of the tumor necrosis factor family(BAFF). In 2011, the US Food and Drugs Administration approved belimumab as a new drug option for SLE patients. This article mainly discusses the mechanism and relevant clinical trials of belimumab and looks forward to its future.
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    • 参考文献(32)
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出版历程
  • 收稿日期:  2019-06-19
  • 刊出日期:  2020-03-30

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