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菱形结构域蛋白在胃癌中的表达

史济华 徐雪 杜俊 崔海梦 许乐 罗庆锋

史济华, 徐雪, 杜俊, 崔海梦, 许乐, 罗庆锋. 菱形结构域蛋白在胃癌中的表达[J]. 协和医学杂志, 2020, 11(2): 151-155. doi: 10.3969/j.issn.1674-9081.20190040
引用本文: 史济华, 徐雪, 杜俊, 崔海梦, 许乐, 罗庆锋. 菱形结构域蛋白在胃癌中的表达[J]. 协和医学杂志, 2020, 11(2): 151-155. doi: 10.3969/j.issn.1674-9081.20190040
Ji-hua SHI, Xue XU, Jun DU, Hai-meng CUI, Le XU, Qing-feng LUO. Expression of RHBDD1 in Gastric Cancer[J]. Medical Journal of Peking Union Medical College Hospital, 2020, 11(2): 151-155. doi: 10.3969/j.issn.1674-9081.20190040
Citation: Ji-hua SHI, Xue XU, Jun DU, Hai-meng CUI, Le XU, Qing-feng LUO. Expression of RHBDD1 in Gastric Cancer[J]. Medical Journal of Peking Union Medical College Hospital, 2020, 11(2): 151-155. doi: 10.3969/j.issn.1674-9081.20190040

菱形结构域蛋白在胃癌中的表达

doi: 10.3969/j.issn.1674-9081.20190040
详细信息
    通讯作者:

    罗庆锋 电话:010-85133834, E-mail:luoqf2000@126.com

  • 中图分类号: R5

Expression of RHBDD1 in Gastric Cancer

More Information
  • 摘要:   目的  评价菱形结构域蛋白(rhomboid domain-containing protein 1, RHBDD1)在胃癌中的表达及其与胃癌发生、发展的关系。  方法  回顾性收集2015年1月至2018年1月北京医院消化内科收治的胃癌、癌前病变以及慢性浅表性胃炎患者的临床资料, 对病变的组织病理学诊断结果进行重新判读。根据病理诊断类型将入组患者的胃黏膜组织分为慢性浅表性胃炎(chronic superficial gastritis, CSG)、低级别上皮内瘤变(low-grade gastric intraepithelial neoplasia, LGIN)、高级别上皮内瘤变(high-grade gastric intraepithelial neoplasia, HGIN)、早期胃癌(early gastric cancer, EGC)和进展期胃癌(advanced gastric cancer, AGC)5组, 记录各组免疫组化检测RHBDD1在胃黏膜组织中的表达阳性率, 分析各组之间的差异。  结果  共76例152处病变入选本研究, 其中CSG 17处, LGIN 21处、HGIN 54处、EGC 44处、AGC 16处。CSG组织中RHBDD1的表达显著低于非CSG病变(LGIN、HGIN、EGC和AGC), 具有统计学差异(χ2=13.157, P=0.001)。病变胃黏膜RHBDD1表达的阳性率随病变严重程度逐渐升高[CSG(35.3%)→癌前病变(LGIN+HGIN)(74.7%)→EGC(75.0%)→AGC(87.5%)]。  结论  胃黏膜组织中RHBDD1的表达有可能为胃部疾病的良恶性鉴别提供有用线索。
    利益冲突  无
  • 图  1  RHBDD1在不同胃黏膜病变中的免疫组化染色强度

    A.慢性浅表性胃炎, RHBDD1表达呈阴性;B.低级别上皮内瘤变, RHBDD1表达呈弱阳性;C.高级别上皮内瘤变, RHBDD1表达呈中等强度阳性;D.早期胃癌, RHBDD1表达呈强阳性RHBDD1:菱形结构域蛋白

    图  2  本研究患者纳入流程图

    表  1  152处不同胃黏膜病变组织中RHBDD1表达水平[n(%)]

    病变类型RHBDD1阴性
    (n=42)
    RHBDD1阳性
    (n=110)
    χ2P
    CSG(n=17)11(64.7)6(35.3)13.1570.001*
    非CSG(n=135)31(23.0)104(77.0)
    LGIN(n=21)6(28.6)15(71.4)
    HGIN(n=54) 12(22.2) 42(77.8)
    EGC(n=44) 11(25.0) 33(75.0)
    AGC(n=16) 2(12.5) 14(87.5)
    CSG:慢性浅表性胃炎;LGIN:胃低级别上皮内瘤变;HGIN:胃高级别上皮内瘤变;EGC:早期胃癌;AGC:进展期胃癌;*CSG与非CSG(LGIN、HGIN、EGC和AGC)相比,P=0.001
    下载: 导出CSV
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出版历程
  • 收稿日期:  2019-02-19
  • 刊出日期:  2020-03-30

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