Abstract: Strengthening the scientific management of antimicrobial agents plus reducing bacterial resistance has become a worldwide urgency and one of the major challenges in public health. The National Special Project of Clinical Application and Management of Antimicrobials has been implemented for 8 years and it has achieved remarkable results. Antimicrobial stewardship program, combined with training, has been developed with the intention of reducing inappropriate and unnecessary use of antimicrobials while improving the quality of patient care and locally helping prevent the development of antimicrobial resistance. Based on data, the change from administrative intervention to a management mode of a long-term technology-supporting system will come true.