Abstract: Tremendous development and progress in clinical hemodynamics have been made since 30 years ago when the first Swan-Ganz Cather was introduced to China. The emerging concept of clinical hemodynamic therapy (CHT) is enriched today in its theoretical system and clinical feasibility. CHT includes some new concepts, such as that hemodynamics is a discipline defining the state of both blood flow and blood component flowing inside and outside of the cardiovascular system. CHT is not as same as hemodynamic monitoring because of its characteristics and its control capability in clinical behavior, which include some key points like therapeutic timing and targeting, interventional therapy, and concomitant injury. The therapeutic target is at the interaction among organs and has changed from personalized therapy to organ-target directed therapy. CHT is a goal-directed, quantitative treatment process in accordance with the patient's real-time status and response to the intervention based on hemodynamic theories.