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难治性胸腹腔积液:不典型恶性间皮瘤一例

林锦璇 孙钢 陈闽江 郭伏平 谢秀丽 马志强 崔全才 应红艳 李晓青

林锦璇, 孙钢, 陈闽江, 郭伏平, 谢秀丽, 马志强, 崔全才, 应红艳, 李晓青. 难治性胸腹腔积液:不典型恶性间皮瘤一例[J]. 协和医学杂志, 2019, 10(4): 423-427. doi: 10.3969/j.issn.1674-9081.2019.04.022
引用本文: 林锦璇, 孙钢, 陈闽江, 郭伏平, 谢秀丽, 马志强, 崔全才, 应红艳, 李晓青. 难治性胸腹腔积液:不典型恶性间皮瘤一例[J]. 协和医学杂志, 2019, 10(4): 423-427. doi: 10.3969/j.issn.1674-9081.2019.04.022
Jin-xuan LIN, Gang SUN, Min-jiang CHEN, Fu-ping GUO, Xiu-li XIE, Zhi-qiang MA, Quan-cai CUI, Hong-yan YING, Xiao-qing LI. Refractory Pleural and Peritoneal Effusion:A Case of Atypical Malignant Mesothelioma[J]. Medical Journal of Peking Union Medical College Hospital, 2019, 10(4): 423-427. doi: 10.3969/j.issn.1674-9081.2019.04.022
Citation: Jin-xuan LIN, Gang SUN, Min-jiang CHEN, Fu-ping GUO, Xiu-li XIE, Zhi-qiang MA, Quan-cai CUI, Hong-yan YING, Xiao-qing LI. Refractory Pleural and Peritoneal Effusion:A Case of Atypical Malignant Mesothelioma[J]. Medical Journal of Peking Union Medical College Hospital, 2019, 10(4): 423-427. doi: 10.3969/j.issn.1674-9081.2019.04.022

难治性胸腹腔积液:不典型恶性间皮瘤一例

doi: 10.3969/j.issn.1674-9081.2019.04.022
基金项目: 

北京协和医学院教学质量工程项目 2017zlgc0110

详细信息
    通讯作者:

    李晓青电话:010-69155017,E-mail:lixiaoqing20060417@126.com

  • 中图分类号: R576;R441.9

Refractory Pleural and Peritoneal Effusion:A Case of Atypical Malignant Mesothelioma

More Information
  • 摘要: 本文报道1例累及胸膜和腹膜的不典型恶性间皮瘤。从临床表现、病理等方面介绍本例患者的不典型之处,并进行文献复习,以加强临床医师对不典型恶性间皮瘤临床不典型表现的认识。
    利益冲突  无
  • 图  1  胸部CT示右侧胸腔积液(2015年9月)

    图  2  胸部CT示右肺中叶胸膜下索条影(箭头),双下肺胸膜下片状磨玻璃影(圆圈)

    图  3  腹盆腔CT增强扫描示左肾前方软组织占位(箭头)

    图  4  腹腔镜下见壁层腹膜弥漫分布白色粟粒状结节(A, 箭头), 子宫表面弥漫分布白色粟粒状结节(B, 箭头)

    图  5  术中切除的大体病理组织

    图  6  光镜病理结果(HE染色,×40)

  • [1] Bibby AC, Tsim S, Kanellakis N, et al. Malignant pleural mesothelioma: an update on investigation, diagnosis and treatment[J]. Eur Respir Rev, 2016, 25: 472-486.
    [2] Sekido Y. Molecular pathogenesis of malignant mesothelioma[J]. Carcinogenesis, 2013, 34: 1413-1419.
    [3] 刘均平, 杨力, 郭新宁.胸腹膜恶性间皮瘤一例[J].中华消化杂志, 2000, 20: 260.
    [4] 刘艳群, 王开绿, 郑晓凤, 等.胸腹膜恶性间皮瘤1例并文献复习[J].临床肺科杂志, 2006, 11: 738.
    [5] 李娜, 轩菡, 陈婷婷.恶性胸膜间皮瘤伴腹膜广泛病变1例报告[J].安徽医学, 2014, 35: 707-708.
    [6] Jiang X, Hidru TH, Zhang Z, et al.Evidence of elemene injection combined radiotherapy in lung cancer treatment among patients with brain metastases: A systematic review and meta-analysis[J]. Medicine (Baltimore), 2017, 96: e6963.
    [7] Henderson DW, Reid G, Kao SC, et al. Challenges and controversies in the diagnosis of mesothelioma: Part 1. Cytology-only diagnosis, biopsies, immunohistochemistry, discrimina-tion between mesothelioma and reactive mesothelial hyperplasia, and biomarkers[J]. J Clin Pathol, 2013, 66: 847-853.
    [8] Arif Q, Husain AN. Malignant Mesothelioma Diagnosis[J]. Arch Pathol Lab Med, 2015, 139: 978-980.
    [9] 刘标, 周晓军.恶性间皮瘤的病理诊断[J].诊断病理学杂志, 2014, 21: 1-3.
    [10] Vogelzang NJ, Rusthoven JJ, Symanowski J, et al. Phase Ⅲ study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma[J]. J Clin Oncol, 2003, 21:2636-2644. https://academic.oup.com/jjco/article/38/5/339/805437
    [11] Van Meerbeeck JP, Gaafar R, Manegold C, et al. Randomized phase Ⅲ study of cisplatin with or without raltitrexed in patients with malignant pleural mesothelioma: an intergroup study of the European Organisation for Research and Treatment of Cancer Lung Cancer Group and the National Cancer Institute of Canada[J]. J Clin Oncol, 2005, 23:6881-6889. https://www.ncbi.nlm.nih.gov/pubmed/16192580
    [12] Zalcman G, Mazieres J, Margery J, et al. Bevacizumab for newly diagnosed pleural mesothelioma in the Mesothelioma Avastin Cisplatin Pemetrexed Study (MAPS): a randomised, controlled, open-label, phase 3 trial[J]. Lancet, 2016, 387:1405-1414. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(15)01238-6/fulltext
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出版历程
  • 收稿日期:  2018-05-04
  • 刊出日期:  2019-07-30

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