Abstract: The intestinal microbiota has a profound effect on human health and diseases. It affects the development of the immune system of the host and vice versa. At present, the intestinal microbiota has been found to be involved in many autoimmune diseases. Gastrointestinal tract involvement is common in patients with systemic sclerosis (SSc). Studies found that the gastric and intestinal flora of SSc patients are in disorder, and some of the specific bacteria are related to the severity of gastrointestinal involvement in SSc patients. In this paper, the related research on the intestinal flora of SSc was reviewed, such as changes in intestinal flora, the relationship between the intestinal flora and dyskinesia and fibrosis of the digestive system, and the progress of treatment.