粪菌移植治疗炎症性肠病的争议

Controversy of Fecal Microbiota Transplantation in Treating Patients with Inflammatory Bowel Disease

  • 摘要: 已有报道表明粪菌移植治疗炎症性肠病前景可观, 且针对溃疡性结肠炎的临床随机对照研究支持粪菌移植的有效性。但涉及粪菌制备的方法学、移植途径、供体筛选、患者选择以及诱发病情活动的潜在风险等方面尚存诸多未知, 因此, 粪菌移植目前仅适合在临床试验等特定条件下用于炎症性肠病治疗。

     

    Abstract: Fecal microbiota transplantation (FMT) is reported to be a promising therapy for patients with inflammatory bowel disease(IBD). Randomized controlled trials have reported the effectiveness of FMT in the treatment of ulcerative colitis. However, many associated unknowns still remain, such as the preparation, the transplantation route, donor and recipient selection, and potential adverse events including the risk of IBD flare post-FMT. Therefore, FMT should only be administered in patients with IBD in a circumstanced setting, such as clinical trials.

     

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