Abstract: The status of mental health and behavior of patients and medical personnel is an important factor affecting the management of patient safety. There is no complete patient safety without the dimension of mental health. However, there is no specific setting about mental health and behavior issue in the management guidelines of patient safety in China and abroad. This paper put forward the viewpoint that "Systematic assessment and intervention of mental health status should be integrated into patient safety management" with reference to the researches in related fields, and suggested that Delph method should be used to carry out exploratory research.