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肠道菌群与人体免疫系统相关性研究方兴未艾

焦禹豪 张奉春

焦禹豪, 张奉春. 肠道菌群与人体免疫系统相关性研究方兴未艾[J]. 协和医学杂志, 2019, 10(3): 193-196. doi: 10.3969/j.issn.1674-9081.2019.03.001
引用本文: 焦禹豪, 张奉春. 肠道菌群与人体免疫系统相关性研究方兴未艾[J]. 协和医学杂志, 2019, 10(3): 193-196. doi: 10.3969/j.issn.1674-9081.2019.03.001
Yu-hao JIAO, Feng-chun ZHANG. New Insights into Research on the Role of Gut Microbiota in Human Immune System[J]. Medical Journal of Peking Union Medical College Hospital, 2019, 10(3): 193-196. doi: 10.3969/j.issn.1674-9081.2019.03.001
Citation: Yu-hao JIAO, Feng-chun ZHANG. New Insights into Research on the Role of Gut Microbiota in Human Immune System[J]. Medical Journal of Peking Union Medical College Hospital, 2019, 10(3): 193-196. doi: 10.3969/j.issn.1674-9081.2019.03.001

肠道菌群与人体免疫系统相关性研究方兴未艾

doi: 10.3969/j.issn.1674-9081.2019.03.001
详细信息
    通讯作者:

    张奉春 电话:010-69158792, E-mail:zhangfccra@aliyun.com

  • 中图分类号: R378;R593

New Insights into Research on the Role of Gut Microbiota in Human Immune System

More Information
  • 摘要: 肠道菌群作为人体中数量众多的异种成分, 与人体免疫系统有着复杂的双向作用。一方面, 菌群和人体的共生依赖于免疫耐受形成; 另一方面肠道相关免疫组织的发育和免疫细胞的激活亦受到源自菌群的异源性信号密切调控。因此, 肠道菌群对于正常免疫系统的建立至关重要, 反之, 免疫系统的改变亦可能造成肠道菌群紊乱, 二者之间的相互作用发生异常可能影响局部乃至全身免疫系统, 进而参与系统性炎症性疾病、自身免疫性疾病以及肿瘤的发病机制。有临床研究表明, 益生菌补充和健康人粪菌移植联合传统免疫治疗能够提高耐药患者的疗效, 提示肠道菌群可能是潜在的重要治疗靶点, 因此了解肠道菌群在人体免疫中的作用非常重要。
    利益冲突  无
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出版历程
  • 收稿日期:  2019-04-23
  • 刊出日期:  2020-09-18

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