Abstract: Pancreatic ductal carcinoma(PDAC)is a highly malignant tumor of the digestive tract. The common problems in its diagnosis and treatment include:(1)screening and early detection; (2)accurate diagnosis and staging; (3)differential diagnosis; (4)follow-up and treatment evaluation, in which imaging plays an important role. This article summarized the role and value of various imaging examinations in the diagnosis and treatment of PDAC, explained the advantages and limitations of various imaging examinations, provided evidence-based PDAC imaging examination process, and focused on the key points of PDAC imaging diagnosis and differential diagnosis, so as to better guide clinical decision-making and improve the prognosis of patients with PDAC.