Abstract: Celiac disease is an immune-mediated intestinal disorder characterized by chronic inflammation of the small intestine, triggered and maintained by exposure to gluten in the diet. The rapid development of technology and a better understanding of the mechanism of celiac disease lead to combining the application of new serologic diagnostic tests, certain genetic markers, and histopathologic evaluation to aid the diagnosis of celiac disease. We reviewed the recent progress and debate of the diagnostic techniques for celiac disease.