Abstract: Goal-directed fluid therapy (GDT), as an important part of enhanced recovery after surgery (ERAS), is of great concern in accelerating the recovery and improving the prognosis after major surgery. Based on existing reports, we summarized some monitoring methods, observation indexes, and liquid selections commonly used in clinical practice, and discussed the application and effects of GDT of ERAS in gastrointestinal surgery, thoracic surgery, liver surgery, head and neck carcinoma surgery. The result showed that GDT had significant advantages for fluid management in major surgery, including decreasing overall complication rate, reducing hospital stays, accelerating recovery, and improving prognosis.