Abstract: The 28th European Conference on Clinical Microbiology and Infectious Diseases (ECCMID) opened with a great ceremony from 21st to 24th, April 2018 in Madrid, Spain. This meeting focused on several hot topics concerning clinical microbiology and infectious diseases，including the breakpoints update of the European Committee on Antimicrobial Susceptibility Testing (EUCAST), EUCAST rapid antimicrobial susceptibility testing by disk diffusion directly from blood culture bottles, HeIP as a new prognostic biomarker for patients with bloodstream infection of Pseudomonas aeruginosa, the comparable effect of 7-day versus 14-day antimicrobial therapy for gram-negative bacteremia, reemergence of West Nile Virus infection in humans in Southern Greece, the implementation of the infection-risk scan in a Dutch hospital resulting in standardization, transparency and substantial improvement, novel mechanisms of fosfomycin resistance in Escherichia coli, the outbreak of Candida auris infection in a UK intensive care unit, mazEF bacterial toxin-antitoxin systems as targets for novel antimicrobials, and so on. Besides, China also showed its stories in the conference, including the first introduction of China Antimicrobial Resistance Surveillance System, the successful hosting of the second work meeting of Chinese Committee on Antimicrobial Susceptibility Testing, and China-Europe Forum of Global Chinese Association of Clinical Microbiology and Infectious Diseases.