Abstract: Infection or shock is such a disease or syndrome that everybody seems to know, and is confronting every clinician because any patient has the opportunity to get it and even worse into septic shock. Infection may induce dysregulated host response to cause life-threatening organ dysfunction. Shock may represent profound circulatory and cellular metabolic abnormalities, and increase mortality substantially. It is very important for every clinician to keep abreast of advances in understanding and managing infection, shock, and septic shock correctly. Septic shock is a common lethal syndrome but is curable and preventable if you and I just do the right things from the beginning.