Abstract: Venous thromboembolism (VTE) is one of the common perioperative complications. The Guidelines for Prevention and Management of Perioperative Venous Thrombosis in General Surgery in China was released in 2016, which makes a lot of pertinent suggestions on VTE risk assessment in patients with general surgery, implementation of prophylactic measures, and perioperative management with anticoagulant medications. It also standardizes and promotes the practice of thrombosis management in the perioperative period of general surgery in China. Based on the interpretation of the guidelines and our own clinical practice, we analyzed in detail the influence of the ethnic differences, different surgical methods, and the type of disease on the incidence of VTE, as well as the selection of risk model and anticoagulation preventive measures for VTE. We hope to provide a further understanding of the clinical perioperative prevention and management of VTE.