Abstract: Due to the rapid development in research of translational medicine, the construction and application of clinical biobank has got increasing attention.The information system is the core of a biobank, which plays an important role in the construction and management of the biobank.The development of information system should be based on supporting the overall process of building, operation, management and service of the clinical biobank.Through establishing the data collecting process of sample information, data exchange system and security systems, all databases are integrated, and public network platforms are established.The Biobank information system could realize efficiently managing and comprehensively sharing all biospecimen, clinical medical records and molecular data.