Abstract: Amyotrophic lateral sclerosis(ALS) is a progressive neurodegenerative disease, characterized by insidious onset, slow progression, and death due to respiratory failure. There is no cure for it. Recent studies show that many measures can prolong the survival of patients with ALS, and improve their quality of life. In order to treat ALS scientifically and rationally, this paper introduces its clinical classification, staging, treatment mode, and methods for evaluating and following up the progress of ALS disease.