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长链非编码RNA在骨关节炎发生发展中的作用

于辰曦 孙水

于辰曦, 孙水. 长链非编码RNA在骨关节炎发生发展中的作用[J]. 协和医学杂志, 2020, 11(1): 85-90. doi: 10.3969/j.issn.1674-9081.20170138
引用本文: 于辰曦, 孙水. 长链非编码RNA在骨关节炎发生发展中的作用[J]. 协和医学杂志, 2020, 11(1): 85-90. doi: 10.3969/j.issn.1674-9081.20170138
Chen-xi YU, Shui SUN. Roles of Long Noncoding RNAs in the Development and Progression of Osteoarthritis[J]. Medical Journal of Peking Union Medical College Hospital, 2020, 11(1): 85-90. doi: 10.3969/j.issn.1674-9081.20170138
Citation: Chen-xi YU, Shui SUN. Roles of Long Noncoding RNAs in the Development and Progression of Osteoarthritis[J]. Medical Journal of Peking Union Medical College Hospital, 2020, 11(1): 85-90. doi: 10.3969/j.issn.1674-9081.20170138

长链非编码RNA在骨关节炎发生发展中的作用

doi: 10.3969/j.issn.1674-9081.20170138
详细信息
    通讯作者:

    孙水 电话:0531-68776351, E-mail:shunshui1965@foxmail.com

  • 中图分类号: R68

Roles of Long Noncoding RNAs in the Development and Progression of Osteoarthritis

More Information
  • 摘要: 骨关节炎(osteoarthritis, OA)是一种老年人中最为常见的慢性关节疾病, 其主要特征表现为关节软骨退行性变, 但确切发病机制尚不十分明确。长链非编码RNA(long non-coding RNAs, lncRNAs)是一种长度超过200个核苷酸的RNA, 缺少开放阅读框和蛋白编码功能。近年来研究发现, lncRNAs在正常关节软骨与OA关节软骨中的表达呈现差异化, 且部分差异化表达的lncRNAs通过调控细胞凋亡、软骨细胞外基质降解、炎症反应、血管生成、细胞自噬、软骨细胞应力响应等过程参与了OA的发生发展。本文将对lncRNAs在OA发生发展中的作用进行综述, 以期为OA的诊断和特异性治疗提供新靶点。
    利益冲突  无
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出版历程
  • 收稿日期:  2017-07-17
  • 刊出日期:  2020-01-30

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